S. Mason

Patterns of Klebsiella pneumoniae bacteremic dissemination from the lung

This study tracks Klebsiella pneumoniae dissemination from the lung using barcoding, revealing two distinct patterns of bacterial spread and their associated host and bacterial factors.

Fitness Factor Genes Conserved within the Multi-species Core Genome of Gram-negative Enterobacterales Species Contribute to Bacteremia Pathogenesis

The paper identifies 18 conserved fitness genes in Enterobacterales species that contribute to bacteremia pathogenesis by testing mutants in a mouse model and finding attenuation in multiple organs.

Interactions between the gut microbiome, dietary restriction, and aging in genetically diverse mice

This study investigates how the gut microbiome interacts with aging and dietary restriction in mice, finding that host genetics significantly influence microbiome features and that dietary restriction does not rejuvenate the microbiome.

Klebsiella pneumoniae causes bacteremia using factors that mediate tissue-specific fitness and resistance to oxidative stress

This study identifies 58 K. pneumoniae genes critical for bloodstream fitness during bacteremia, revealing tissue-specific mechanisms and resistance to oxidative stress.

Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function

CAFs with a myofibroblastic-like phenotype transfer proteins to ECs, including plasma membrane receptors, through matrix-bound EVs.

The Klebsiella pneumoniae ter operon enhances stress tolerance

This study identifies the ter operon in Klebsiella pneumoniae as a stress tolerance factor, enhancing fitness in the gut and bladder by protecting against environmental stressors.

Spatial regulation of the glycocalyx component Podocalyxin is a switch for pro-metastatic function

This study identifies PODXL as a decoy receptor for GAL3, revealing its role in promoting metastasis through integrin-based invasion and differential cortical targeting regulated by ubiquitination.

The small GTPase ARF3 controls metastasis and invasion modality by regulating N-cadherin levels.

This study identifies ARF3 as a regulator of invasion modality and metastasis in prostate cancer by controlling N-cadherin levels.

Dual G9A and EZH2 inhibition stimulates an anti-tumour immune response in ovarian high-grade serous carcinoma

This study shows that dual inhibition of G9A and EZH2 in ovarian cancer enhances anti-tumour immune responses by altering the immune microenvironment and reducing tumour growth.

THEM6-mediated lipid remodelling sustains stress resistance in cancer

This study identifies THEM6 as a marker of ADT resistance in prostate cancer, showing its role in lipid homeostasis and stress response, and highlights it as a potential therapeutic target.

Spatial enrichment of phosphoinositide metabolism is a molecular switch to promote metastasis.

This study identifies IQSEC1 variants that spatially regulate phosphoinositide metabolism to switch cell behavior from growth to invasion, with implications for metastasis.

Monocytes mediate Salmonella Typhimurium-induced tumour growth inhibition

This study shows that Salmonella Typhimurium SL7207 inhibits melanoma growth by recruiting pro-inflammatory monocytes, and blocking these monocytes reverses the anti-tumor effect.

A plasmid locus associated with Klebsiella clinical infections encodes a microbiome-dependent gut fitness factor

The paper identifies a plasmid-encoded ter operon in Klebsiella pneumoniae that functions as a microbiome-dependent gut fitness factor, enhancing colonization in the presence of specific gut microbiota.

RUNX/CBFβ transcription factor complexes promote the phenotypic plasticity of metastatic breast cancer cells

This study shows that RUNX/CBFβ complexes drive phenotypic plasticity in metastatic breast cancer cells by promoting EMT and enabling MET reversal.