Author

I. Holen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

J. K. Hobbs· 2 shared N. J. Brown· 2 shared N. Mullin· 2 shared R. Hughes· 2 shared X. Chen· 2 shared A. Fowles· 1 shared A. Mastro· 1 shared H. Harrison· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

J. K. Hobbs

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Atomic force microscopy reveals the mechanical properties of breast cancer bone metastases

X. Chen, R. Hughes, N. Mullin, R. J. Hawkins, I. Holen, N. J. Brown, J. K. Hobbs

This study uses atomic force microscopy to measure the mechanical properties of breast cancer bone metastases and finds they are more compliant than other cancer models.

Nanoscale · Jan 1, 2021Peer-reviewedCancer Biology

Mechanical Heterogeneity in the Bone Microenvironment as Characterised by Atomic Force Microscopy

J. K. Hobbs, X. Chen, N. Mullin, R. Hawkins, N. J. Brown, I. Holen, R. Hughes

This study uses atomic force microscopy to characterize the mechanical heterogeneity of different regions in murine bones, revealing significant variations in elastic and viscoelastic properties across age and tissue types.

bioRxiv · Feb 25, 2020Biophysics

RUNX/CBFβ transcription factor complexes promote the phenotypic plasticity of metastatic breast cancer cells

R. Ran, H. Harrison, N. S. Ariffin, R. Ayub, H. Pegg, W. Deng, A. Mastro, P. Ottewell, A. Fowles, S. Mason, K. Blythe, I. Holen, P. Shore

This study shows that RUNX/CBFβ complexes drive phenotypic plasticity in metastatic breast cancer cells by promoting EMT and enabling MET reversal.

bioRxiv · Feb 27, 2019 · PreprintCancer Biology