PhysiologybioRxivPreprint
Pharmacological or genetic inhibition of Scn9a protects human and mouse beta cells while dampening insulin secretion in type 1 diabetes
P. Overby, A. G. Gordon, X.-Q. Dai…·J. D. Johnson
This study shows that inhibiting Scn9a protects beta cells in type 1 diabetes by reducing excitability and improving survival, while also dampening insulin secretion.