A. G. Hughson

The paper determines the near-atomic structure of two prion strains from the same host genotype, revealing conformational differences that underlie strain-specific characteristics.

Cryo-electron microscopy reveals a near-atomic structure of an infectious, brain-derived murine prion fibril and strain differences.

This paper determines the structure of an infectious mammalian prion using cryo-electron microscopy, revealing its fibril architecture and molecular features involved in propagation.