Evolution is not uniform along protein sequences
R. Bricout, D. Weil, D. Stroebel, A. Genovesio, H. Roest Crollius
The paper shows amino acids at protein termini evolve twice as fast as those in the center, due to weaker functional constraints, and highlights biases in selection inference methods.
bioRxiv · Apr 30, 2022 · PreprintEvolutionary Biology