Author

D. Eeckhout

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Biology Disciplines

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Plant Biology· 8 Cell Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 12 Research Focus:cell type annotation· 8 Organism:Arabidopsis· 7 Assay:proteomics· 7 Research Focus:cell signaling & trafficking· 5 Organism:plant (other)· 5 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:development & morphogenesis· 3

Frequent Co-Authors

G. De Jaeger· 11 shared D. van Damme· 8 shared K. Gevaert· 4 shared K. Yperman· 4 shared M. Vandorpe· 4 shared E. Mylle· 3 shared J. Van Leene· 3 shared M. Potocky· 3 shared

Activity by Year

2018-2024 · peak 4/yr

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10 top collaborators · 38 mutual co-author links

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11 shared papersPlant Biology

G. De Jaeger

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12 papers

Recent·Most cited

Implementation of pupylation-based proximity labelling in plant biology reveals regulatory factors in cellulose biosynthesis

S. Zheng, O. Khammy, L. Noack, A. De Meyer, G. Khan, N. De Winne, D. Eeckhout, D. van Damme, S. Persson

The paper introduces PUP-IT, a pupylation-based proximity labelling method for detecting protein interactions in plants, and identifies BEN1 as a regulator of cellulose synthesis.

bioRxiv · Jan 9, 2024 · PreprintPlant Biology

Mapping the adaptor protein complex interaction network in Arabidopsis identifies P34 as a common stability regulator

P. Wang, W. Siao, X. Zhao, D. Arora, R. Wang, D. Eeckhout, J. Van Leene, R. Kumar, A. Houbaert, N. De Winne, E. Mylle, M. Vandorpe, R. A. Korver, C. Testerink, K. Gevaert, , E. Russinova

The paper maps AP complex interactions in Arabidopsis, identifying P34 as a stability regulator of clathrin-mediated endocytosis and post-Golgi trafficking.

bioRxiv · Aug 31, 2022 · PreprintPlant Biology

Biomolecular condensation orchestrates clathrin-mediated endocytosis in plants

J. M. Dragwidge, Y. Wang, L. Brocard, A. De Meyer, R. Hudecek, D. Eeckhout, P. Grones, M. Buridan, C. Chambaud, P. Pejchar, M. Potocky, J. Winkler, M. Vandorpe, N. Serre, M. Fendrych, , D. Van Damme

This study shows that AtEH1 and AtEH2 subunits of the TPC complex drive biomolecular condensation to facilitate clathrin-mediated endocytosis in plants, with their disordered regions regulating condensate properties and endocytosis dynamics.

bioRxiv · Mar 17, 2022Cell Biology

Proteomic Characterization of Isolated Arabidopsis Clathrin-Coated Vesicles Reveals Evolutionarily Conserved and Plant Specific Components

D. A. Dahhan, G. D. Reynolds, J. J. Cardenas, D. Eeckhout, A. Johnson, K. Yperman, W. Kaufmann, N. Vang, X. Yan, I. Hwang, A. Heese, G. De Jaeger, J. Friml, D. Van Damme, J. Pan, S. Y. Bednarek

The paper characterizes the proteome of Arabidopsis clathrin-coated vesicles, identifying conserved and plant-specific components involved in clathrin-mediated trafficking.

bioRxiv · Sep 16, 2021Cell Biology

SAMBA controls the rate of cell division in maize development through APC/C interaction

P. Gong, M. Bontinck, K. Demuynck, J. De Block, K. Gevaert, D. Eeckhout, G. Persiau, S. Aesaert, G. Coussens, M. Van Lijsebettens, L. Pauwels, G. De Jaeger, D. Inze, H. Nelissen

This study shows that SAMBA regulates cell division rate in maize by interacting with APC/C, with different alleles causing varying growth defects due to altered protein function.

bioRxiv · Apr 22, 2021 · PreprintPlant Biology

Arabidopsis Casein Kinase 2 triggers Stem Cell Exhaustion under Al Toxicity and Phosphate Deficiency Through activation of the DNA Damage Response pathway

W. Pengliang, M. Demulder, P. David, T. Eekhout, K. O. Yoshiyama, L. Nguyen, I. Vercauteren, D. Eeckhout, M. Galle, G. De Jaeger, P. Larsen, D. Audenaert, T. Desnos, L. Nussaume, R. Loris, L. De Veylder

The paper identifies CK2 and DNA damage response regulators as key factors in controlling Arabidopsis root growth under Al toxicity and phosphate limitation.

bioRxiv · Nov 30, 2020Plant Biology

The TPLATE subunit is essential for structural assembly of the endocytic TSET complex

K. Yperman, J. Wang, D. Eeckhout, J. Winkler, L. Vu, M. Vandorpe, P. Grones, E. Mylle, M. Kraus, R. Merceron, J. Nolf, E. Mor, P. De Bruyn, R. Loris, M. Potocky, , R. Pleskot

The paper determines the structural architecture of the plant TSET complex and identifies key interactions essential for its assembly and function in endocytosis.

bioRxiv · Aug 13, 2020 · PreprintCell Biology

Distinct EH domains of the endocytic TPLATE complex confer lipid and protein binding.

K. Yperman, A. C. Papageorgiou, R. Merceron, S. De Munck, Y. Bloch, D. Eeckhout, P. Tack, T. Evangelidis, J. Van Leene, L. Vincze, P. Vandenabeele, M. Potocky, G. De Jaeger, S. N. Savvides, K. Tripsianes, , D. Van Damme

This study identifies distinct lipid and protein binding roles of EH domains in the TPLATE complex, revealing their functional contributions to plant clathrin-mediated endocytosis.

bioRxiv · May 29, 2020Plant Biology

Establishment of Proximity-dependent Biotinylation Approaches in Different Plant Model Systems

D. Arora, N. B. Abel, C. Liu, P. Van Damme, K. Yperman, L. Dai Vu, J. Wang, A. Tornkvist, F. Impens, B. Korbei, D. Eeckhout, J. Van Leene, A. Goossens, G. De Jaeger, T. Ott, , D. Van Damme

The paper establishes TurboID as the most effective PDL method in plant systems and demonstrates its utility in capturing protein interactomes and structural information.

bioRxiv · Mar 27, 2020Plant Biology

The deubiquitinating enzymes UBP12 and UBP13 negatively regulate the activity of the ubiquitin-dependent peptidases DA1, DAR1 and DAR2

D. Inze, H. Vanhaeren, Y. Chen, M. Vermeersch, V. De Vleeschhauwer, G. Persiau, D. Eeckhout, G. De Jaeger, K. Gevaert

The paper shows that UBP12 and UBP13 deubiquitinate DA1, DAR1, and DAR2, reducing their activity and affecting plant growth and development.

bioRxiv · Oct 14, 2019 · PreprintPlant Biology

The TPX-Like protein 3TPXL, but not TPX2, is the primary activator of α Aurora kinases and is essential for embryogenesis in Arabidopsis

J. Boruc, X. Deng, E. Mylle, N. Besbrugge, M. Van Durme, D. Demidov, T.-R. C. Tan, E. D. Tomastikova, M. Vandorpe, D. Eeckhout, T. Beeckman, M. Nowack, G. De Jaeger, H. Lin, B. Liu, D. Van Damme

The paper identifies TPXL3 as the primary activator of α Aurora kinases in Arabidopsis, essential for embryogenesis, while TPX2 and TPXL2 have distinct roles.

bioRxiv · Oct 1, 2018Cell Biology

DET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis

A. Nassrallah, M. Rougee, C. Bourbousse, S. Drevensek, S. Fonseca, E. Iniesto, O. Ait-Mohamed, A.-F. Deton-Cabanillas, G. Zabulon, I. Ahmed, D. Stroebel, V. Masson, B. Lombard, D. Eeckhout, K. Gevaert, , F. Barneche

The paper shows DET1 regulates H2Bub homeostasis in Arabidopsis by controlling the stability of a DUBm through interaction with DDA1.

bioRxiv · Apr 30, 2018Plant Biology