MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles.
L. Peters, L. Rakateli, R. Huchzermeier, A. Bonnin-Marquez, S. L. Maas, C. Lin, A. Jans, Y. Geng, A. Gorter, M. Gijbels, S. Rensen, P. Olinga, T. Hendrikx, M. Krawczyk, M. Brisbois, , E. P. C. van der Vorst
This paper shows that miR-26b deficiency worsens MASH in mice, and that miR-26b mimic-loaded LNPs can reverse these effects.
bioRxiv · Feb 18, 2024Pathology