C. Weber

Control of cholesterol-induced adipocyte inflammation by the Nfe2l1-Atf3 pathway

This study identifies the Nfe2l1-Atf3 pathway as a regulator of cholesterol-induced adipocyte inflammation and insulin resistance in both human and mouse models.

Macroscopic label-free biomedical imaging withshortwave infrared Raman scattering

This paper introduces a shortwave infrared Raman imaging technique that enables label-free, high-contrast visualization of tissue composition and pathology without contrast agents.

Endothelial cannabinoid CB1 receptor deficiency reduces arterial inflammation and lipid uptake in response to atheroprone shear stress

This paper shows that blocking endothelial CB1 receptors reduces arterial inflammation and lipid uptake under atheroprone shear stress, suggesting potential therapeutic benefits for atherosclerosis.

The tricellular junction protein ILDR2 in glomerulopathies: insights and implications

This study investigates ILDR2's role in glomerulopathies, finding it upregulated in disease models and suggesting a protective effect against glomerular damage.

MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles.

This paper shows that miR-26b deficiency worsens MASH in mice, and that miR-26b mimic-loaded LNPs can reverse these effects.

Gene Therapy for Cardiomyopathy associated with Duchenne Muscular Dystrophy in a Pig Model

This study shows that AAV1.SERCA2a gene therapy improves heart function and reduces arrhythmia in a pig model of Duchenne muscular dystrophy.

Inflammation-Induced Claudin-2 Upregulation Limits Pancreatitis Progression by Enhancing Tight Junction-Controlled Pancreatic Ductal Transport

This study shows CLDN2 upregulation during pancreatitis limits disease progression by enhancing tight junction-controlled fluid transport in pancreatic ductal epithelium.

Assembly of tight junction belts by surface condensation and actin elongation

The paper investigates how surface phase transitions control protein condensation to form tight junction belts through ZO-scaffold proteins and actin polymerization.

Loss of myeloid cannabinoid CB1 receptor confers atheroprotection by reducing macrophage proliferation and immunometabolic reprogramming

This study shows that loss of myeloid CB1 receptor reduces atherosclerosis in male mice by limiting macrophage proliferation and inflammation, with sex-specific effects observed.

The Cohesin ATPase cycle is mediated by specific conformational dynamics and interface plasticity of SMC1A and SMC3 ATPase domains

This study characterizes the ATPase cycle of Cohesin by showing how SMC1A and SMC3 domains undergo structural changes, revealing the role of interface plasticity in the cycle.

GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight in obese mice

This study shows that GIP receptor agonism reduces dyslipidemia and atherosclerosis in obese mice without affecting body weight.

OrganoID: a versatile deep learning platform for tracking and analysis of single-organoid dynamics

OrganoID automatically tracks and analyzes single-organoid dynamics in microscopy images, showing high accuracy in counting, sizing, and morphology analysis across multiple organoid types.

A synthetic bispecific antibody capable of neutralizing SARS-CoV-2 Delta and Omicron

This paper describes a synthetic bispecific antibody that neutralizes SARS-CoV-2 Delta and Omicron variants with picomolar affinity.

MIF-2/D-DT is an atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis

This study identifies MIF-2 as an atherogenic chemokine that promotes atherosclerosis and hepatic lipogenesis by acting through CXCR4 and SREBP pathways.

GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation

This study shows that GPR55 in B cells reduces atherosclerosis by regulating plasma cell maturation and antibody production.

Link between aging and atheroprotection in Mif-deficient atherosclerotic mice

This study investigates how Mif deficiency affects atheroprotection in aging Apoe-/- mice, finding that atheroprotective effects diminish with age.

Heterocomplexes between the Atypical Chemokine MIF and the CXC-Motif Chemokine CXCL4L1 Regulate Inflammation and Thrombus Formation

This study identifies a novel interaction between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1, showing that their heterocomplex formation modulates inflammation and thrombus formation.

Direct addition of poly-lysine or poly-ethylenimine to the medium, a simple alternative to plate pre-coating

The paper demonstrates that directly adding poly-ethylenimine or poly-D-lysine to cell culture medium effectively anchors HEK 293 cells, eliminating the need for time-consuming plate pre-coating.

Echidna: integrated simulations of single-cell immune receptor repertoires and transcriptomes

Echidna simulates single-cell immune receptor repertoires and transcriptomes, enabling benchmarking of clonotyping and phylogenetic analysis tools.

Sensitive visualization of SARS-CoV-2 RNA with CoronaFISH

This paper introduces CoronaFISH, a method to visualize SARS-CoV-2 RNA in cells and tissues, demonstrating its sensitivity and applicability in various biological contexts.

Liquid condensates increase potency of amyloid fibril inhibitors

The paper investigates how liquid condensates enhance the potency of amyloid fibril inhibitors by colocalizing inhibitors and aggregates within condensates.