Y. Geng

MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles.

This paper shows that miR-26b deficiency worsens MASH in mice, and that miR-26b mimic-loaded LNPs can reverse these effects.

Restricted intake of sulfur-containing amino acids reversed the hepatic injury induced by excess Desulfovibrio through gut-liver axis

The paper shows that restricting sulfur-containing amino acids reduces liver injury caused by excess Desulfovibrio by lowering bile acids and improving liver function.

Using population dynamics to count bacteriophages and their lysogens

This paper introduces a high-throughput method to count bacteriophages and their lysogens by analyzing post-infection growth dynamics and uses mathematical modeling to infer viral and host interactions.

O-GlcNAcylation of YTHDF2 antagonizes ERK-dependent phosphorylation and inhibits lung carcinoma

This study identifies O-GlcNAcylation of YTHDF2 at Thr-49 as a regulator of ERK-dependent phosphorylation and tumor growth in lung carcinoma.

SARS-CoV-2 Omicron infection augments the magnitude and durability of systemic and mucosal immunity in triple-dose CoronaVac recipients

This study examines immune responses in CoronaVac-vaccinated individuals after Omicron infection, showing enhanced antibody and cellular immunity compared to unvaccinated controls.

Metabolic Nutrient Preferences of Vibrio mimicus: Leveraging Nucleotides and Oligopeptides from Yellow Catfish for Enhanced Infectivity

This study identifies host-specific metabolites that enhance Vibrio mimicus infectivity in yellow catfish by providing nutrients like deoxyguanosine.

Skin permeable polymer for noninvasive transdermal insulin delivery

This paper develops a polymer, OPDMA, that enables noninvasive transdermal insulin delivery in diabetic mice and minipigs, achieving hypoglycemic effects comparable to subcutaneous injection.

Distributable, Metabolic PET Reporting of Tuberculosis

This paper introduces [18F]FDT, a PET tracer that specifically images Mycobacterium tuberculosis lesions and monitors treatment, enabling global access through a simple synthesis method from [18F]FDG.

Artificial intelligence-driven morphology-based enrichment of malignant cells from body fluid

This study uses deep learning and microfluidic sorting to enrich malignant cells from body fluids, improving detection of tumor fractions and mutations.

Sirt3 enhanced Bufalin sensitivity of colorectal cancer cells through P53-dependent pathway of apoptosis Sirt3 enhanced Bufalin sensitivity of colorectal cancer cells through P53-dependent pathway of apoptosis

An allosteric agonist activates BK channels by perturbing coupling between Ca2+ binding and pore opening

The paper identifies BC5, an allosteric agonist that modulates BK channel activation by disrupting the coupling between Ca2+ binding and pore opening.

A spatial stochastic model reveals the role of supercoiling in transcription regulation

This paper develops a spatial stochastic model to show how supercoiling affects transcription regulation in E. coli by enabling communication between RNA polymerase molecules and coordinating gene expression.

Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells

This study develops an organoid-based method to generate large quantities of NK cells from human pluripotent stem cells without feeder cells, achieving efficient and scalable iNK cell production.

Hoxb5 reprograms murine multipotent blood progenitors into hematopoietic stem cell-like cells

This study shows that Hoxb5 can convert multipotent blood progenitors into hematopoietic stem cell-like cells with long-term repopulating ability.

Social behavioral profiling by unsupervised deep learning reveals a stimulative effect of dopamine D3 agonists on zebrafish sociality

The paper develops ZeChat, a deep learning-based assay to analyze zebrafish social behavior, revealing that dopamine D3 agonists enhance sociality.

Top2a promotes the development of social behavior via PRC2 and H3K27me3

The paper identifies Top2a as a key factor in social behavior development through PRC2 and H3K27me3 in zebrafish and mice.

Regeneration of humoral immunity from pluripotent stem cells by defined transcription factors

This study regenerates functional B lymphopoiesis from pluripotent stem cells (PSCs) using Runx1, Hoxa9, and Lhx2, producing antigen-specific antibodies and immune memory in B-cell deficient animals.

Structural insights into the activation of human calcium-sensing receptor

The paper presents cryo-EM structures of the human calcium-sensing receptor in inactive and active states, revealing structural changes during activation.

Alisertib exerts KRAS allele specific anticancer effects in colorectal cancer

This study investigates how Alisertib affects KRAS mutations in colorectal cancer cells, showing allele-specific effects on RAS signaling and cell death mechanisms.

CAS-LiveFISH: Simple and versatile imaging of genomic loci in live mammalian cells and early pre-implantation embryos

The paper introduces CAS-LiveFISH, a method for imaging genomic loci in live cells and embryos using sgRNA and dCas9 RNPs, enabling multiplex tagging and high-resolution tracking.

Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathway

This study shows that deleting Nupr1 in HSCs activates quiescence, enhancing engraftment without affecting stemness or differentiation.

Mesenchymal stem cells suppress leukemia via macrophage-mediated functional restoration of bone marrow microenvironment

This study shows that intra-BM MSC transfusion restores the BM microenvironment, suppresses leukemia, and reprograms macrophages to reduce tumor burden.

Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors

This study demonstrates that transient expression of Runx1 and Hoxa9 in pluripotent stem cells generates functional T cells capable of immune surveillance and tumor eradication.

Using eDNA to Detect the Distribution and Density of Invasive Crayfish in the Honghe-Hani Rice Terrace World Heritage Site

This study tests eDNA detection for invasive crayfish in rice terraces, finding it more sensitive than trapping and suggesting repeated sampling for reliable monitoring.