A. Griffin

Prenatal inflammation reprograms hyperactive ILC2s that promote allergic lung inflammation and airway dysfunction

Prenatal inflammation induces hyperactivated ILC2s in the developing lung, leading to increased asthma susceptibility through immune remodeling.

Genomic epidemiology of European Aspergillus fumigatus causing COVID-19-associated pulmonary aspergillosis in Europe

This study analyzes the genomic epidemiology of Aspergillus fumigatus causing CAPA in Europe, finding no unique genetic background but a notable prevalence of azole-resistance alleles.

Gene conversion limits the cost of asexuality in somatically immortal worms

The paper investigates how gene conversion in stem cells helps asexual planarians avoid deleterious mutations, suggesting it limits the cost of asexuality.

Molnupiravir (MK-4482) is efficacious against Omicron and other SARS-CoV-2 variants in the Syrian hamster COVID-19 model

MK-4482 inhibits replication of multiple SARS-CoV-2 variants of concern, including Omicron, in the Syrian hamster model.

Serum from COVID-19 patients early in the pandemic shows limited evidence of cross-neutralization against variants of concern

The paper examines serum from early pandemic SARS-CoV-2 patients, finding limited cross-neutralization against variants of concern.

Developmental and MAPK-responsive transcription factors drive distinct malignant subtypes and genetic dependencies in pancreatic cancer

The paper identifies three developmental lineages in pancreatic cancer driven by master regulators and shows their association with MAPK activity and therapeutic vulnerabilities.