Developmental and MAPK-responsive transcription factors drive distinct malignant subtypes and genetic dependencies in pancreatic cancer
P. Laise, M. Turunen, A. Curiel Garcia, L. Tomassoni, C. Maurer, E. Elyada, B. Schmierer, J. Worley, J. Kesner, X. Tan, E. Calvo Fernandez, K. Wong, U. Wasko, S. Tagore, A. L. E. Wang, , A. Califano
The paper identifies three developmental lineages in pancreatic cancer driven by master regulators and shows their association with MAPK activity and therapeutic vulnerabilities.
bioRxiv · Oct 27, 2020 · PreprintCancer Biology