K. Wong

Lower Airway Dysbiosis in NTM+ Bronchiectasis is Associated with NET-Predominant Severe Phenotypes

This study links lower airway microbiota and neutrophilic inflammation in NTM+ bronchiectasis to severe disease phenotypes through network analysis and preclinical models.

Coral species-specific loss and physiological legacy effects are elicited by extended marine heatwave

This study examines how extended marine heatwaves affect two coral species, showing species-specific physiological responses and legacy effects.

Rational design of a SOCS1-edited tumor infiltrating lymphocyte therapy for solid tumors using CRISPR/Cas9 screens

This study uses CRISPR/Cas9 screens to identify SOCS1 as a target for enhancing T cell therapy, leading to the development of an engineered TIL therapy with improved anti-tumor function.

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication

This study identifies the role of G3BP1-N interaction in SARS-CoV-2 replication by showing that disrupting this interaction reduces viral replication and pathogenesis.

Identification of small molecule inhibitors of G3BP-driven stress granule formation

This study identifies two small molecules that inhibit G3BP-driven stress granule formation and dissolve pre-existing granules, showing broad efficacy across cell types and stressors.

Procognitive and neurotrophic benefits of α5-GABA-A receptor positive allosteric modulation in a beta-amyloid deposition model of Alzheimer's disease pathology

This study shows that GL-II-73, a 5-GABAAR positive allosteric modulator, improves cognitive function and neuronal structure in Alzheimer's disease models despite beta-amyloid accumulation.

HIRA loss transforms FH-deficient cells

This study identifies HIRA depletion as a factor that enhances proliferation and invasion of Fh1-deficient cells, revealing a mechanism involving MYC activation and nucleotide metabolism.

Metagenomic analysis of coprolites from three Late Pleistocene megaherbivores from the Southwestern United States.

This study analyzes metagenomic data from coprolites of three Late Pleistocene megaherbivores to assess how desiccation affects microbial community composition compared to modern samples.

WESTPA 2.0: High-performance upgrades for weighted ensemble simulations and analysis of longer-timescale applications

The paper introduces WESTPA 2.0, an upgraded software package for weighted ensemble simulations, enhancing efficiency and analysis of longer-timescale applications.

Genomically mined acoustic reporter genes enable real-time in vivo monitoring of tumors and tumor-homing probiotics

The paper develops improved acoustic reporter genes for real-time in vivo tumor and therapeutic bacteria monitoring in mouse models.

Developmental and MAPK-responsive transcription factors drive distinct malignant subtypes and genetic dependencies in pancreatic cancer

The paper identifies three developmental lineages in pancreatic cancer driven by master regulators and shows their association with MAPK activity and therapeutic vulnerabilities.

Isoform-specific aPKC renders primary cilia dispensable for Hedgehog signaling and basal cell carcinoma growth

The paper shows that aPKC isoforms sustain HH signaling and BCC growth without primary cilia by compensating for ciliary loss in advanced cancers.

Nod-like receptors are critical for gut-brain axis signaling

This study identifies Nod1 and Nod2 as critical regulators of gut-brain axis signaling, showing their role in stress-induced behavioral and physiological changes.

Multi-ATOM: Ultrahigh-throughput single-cell quantitative phase imaging with subcellular resolution

The paper introduces multi-ATOM, a high-throughput QPI method that enables subcellular resolution and accurate cell-type classification without compromising speed or quality.