Resistance to Spindle Inhibitors in Glioblastoma Depends on STAT3 and Therapy Induced Senescence
S. S. Rosenfeld, N. Zarco, A. Dovas, V. Farias, N. Nagaiah, A. Haddock, P. Sims, D. Hambardzumyan, C. T. Meyer, P. Canoll, R. Kenchappa
This study identifies STAT3 as a key driver of resistance to spindle inhibitors in glioblastoma, showing that therapy-induced senescence contributes to drug resistance by promoting quiescence and secreting factors that induce quiescence in proliferating cells.
bioRxiv · Jun 9, 2024Cancer Biology