Continuous hypermutation and evolution of luciferase variants
Tanya Hadjian, Ria A. Deshpande, Zachary R. Torrey, A. Hammond, Rosana S. Molina, Kevin K. Ng, Chang C. Liu, Jennifer A. Prescher
This paper introduces a streamlined platform for luciferase engineering using continuous hypermutation, resulting in improved light output variants without manual library generation.
ACS Chemical Biology · Dec 15, 2025Peer-reviewedBiochemistry