Author

H. M. Hoffman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:metabolism & bioenergetics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Gonzalez· 2 shared P. Zhou· 2 shared R. H. Mak· 2 shared R. Zheng· 2 shared S. Hao· 2 shared W. W. Cheung· 2 shared Z. Wang· 2 shared A. Chu· 1 shared

Activity by Year

2020-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersPhysiology

A. Gonzalez

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Single-Cell Transcriptomic Analysis of Livers During NLRP3 Inflammasome Activation Reveals a Novel Immune Niche

D. M. Calcagno, A. Chu, S. Gaul, N. Taghdiri, A. Toomu, A. Leszczynska, B. Kaufmann, A. Wree, L. Geisler, H. M. Hoffman, A. E. Feldstein, K. R. King

This study uses single-cell transcriptomics to show NLRP3 activation in mice causes chronic extramedullary myelopoiesis and fibrosis in the liver.

bioRxiv · Mar 31, 2021 · PreprintImmunology

The Human Milk Oligosaccharide 3-Sialyllactose Promotes Inflammation Resolution and Reduces Atherosclerosis Development in Mice.

A. R. Pessentheiner, N. J. Spann, C. A. Autran, B. Ramms, A. W. T. Chiang, K. V. Grunddal, Y. Wang, A. Quach, L. M. Booshehri, A. Hammond, C. Tognaccini, J. Latasiewicz, j. L. Witztum, H. M. Hoffman, N. E. Lewis, , P. L. S. M. Gordts

This study shows that 3-sialyllactose reduces inflammation and atherosclerosis in mice by modulating transcriptional activity in macrophages.

bioRxiv · Mar 19, 2021Immunology

Targeting interleukin-1 for reversing fat browning and muscle wasting in infantile nephropathic cystinosis

W. W. Cheung, S. Hao, R. Zheng, Z. Wang, A. Gonzalez, P. Zhou, H. M. Hoffman, R. H. Mak

This paper shows that anakinra, an IL-1 receptor antagonist, reduces fat browning and muscle wasting in Ctns-/- mice, suggesting it could treat cachexia in infantile nephropathic cystinosis.

bioRxiv · Feb 5, 2021Physiology

The role of IL-1 in adipose browning and muscle wasting in CKD-associated cachexia

W. W. Cheung, R. Zheng, S. Hao, Z. Wang, A. Gonzalez, P. Zhou, H. M. Hoffman, R. H. Mak

This study shows that blocking IL-1 receptor reduces adipose browning and muscle wasting in CKD-associated cachexia in mice.

bioRxiv · Feb 5, 2021Physiology

Inhibition of the NLRP3 inflammasome prevents ovarian aging

J. M. Navarro-Pando, E. Alcocer-Gomez, B. Castejon-Vega, J. Muntane, C. Wang, H. M. Hoffman, A. Sanz, G. Mbalaviele, B. Ryffel, M. D. Cordero

This study shows that inhibiting the NLRP3 inflammasome improves ovarian function and fertility in aging mice by enhancing AMH, autophagy, and reducing FSH and estradiol levels.

bioRxiv · Apr 26, 2020Immunology