Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX
T. Shirasaki, H. Feng, H. M. E. Duyvesteyn, W. G. Fusco, K. L. McKnight, L. Xie, M. Boyce, S. Kumar, R. Barouch-Bentov, O. Gonzalez-Lopez, R. McNamara, L. Wang, A. Hertel-Wulff, X. Chen, S. Einav, , S. M. Lemon
This study identifies a viral export signal in hepatitis A virus that requires dual recruitment of HD-PTP and ALIX for nonlytic release in extracellular vesicles.
bioRxiv · Apr 26, 2022Microbiology