H. Feng

Ancestral SARS-CoV-2 immune imprinting persists on RBD but not NTD after sequential Omicron infections

The paper examines how sequential Omicron infections affect ancestral SARS-CoV-2 immune imprinting, finding that it persists on the RBD but not the NTD.

Natural selection and evolution of mitochondrial genome in terrestrial and aquatic turbellarians

This study examines the mitochondrial genome evolution in turbellarians, finding greater selection pressure in aquatic species and identifying NAD4 as a key gene under positive selection.

PFKP regulates AXL-MET oncogenic and metabolic pathways in lung cancer

This study shows PFKP promotes lung cancer progression by interacting with the AXL-MET pathway, beyond its metabolic role in glycolysis.

Systematic Identification of UBE2C As a Prognostic Biomarker and Correlated with Immunosuppression and Invasiveness in Glioma

This study identifies UBE2C as a prognostic biomarker in glioma, linked to immunosuppression and invasiveness through IL6/IL10 and MMP pathways.

Pooled CRISPR interference screening identifies crucial transcription factors in gas-fermenting Clostridium ljungdahlii

This study uses CRISPRi screening to identify transcription factors crucial for growth and carbon utilization in Clostridium ljungdahlii, improving ethanol production through deoR optimization.

Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats

This study develops a CKD-PH rat model through 5/6 nephrectomy and high-salt diet, showing increased Ang II and RAAS imbalance, ACE2 downregulation, and metabolic changes linked to pulmonary hypertension.

Genome and tissue-specific transcriptome of the tropical milkweed (Asclepias curassavica)

This study presents the genome and transcriptome of Asclepias curassavica, revealing tissue-specific gene expression and cardiac glycoside biosynthesis-related genes.

Integrated Hfq-interacting RNAome and transcriptomic analysis reveals complex regulatory networks of nitrogen fixation in root-associated Pseudomonas stutzeri A1501

This study identifies Hfq-binding RNAs in Pseudomonas stutzeri A1501 using eCLIP-seq, revealing new regulatory targets involved in nitrogen fixation and other metabolic processes.

Rapid Development of a Mucosal Nanoparticle Flu Vaccine by Genetic Engineering of Bacteriophage T4 using CRISPR-Cas

This study develops a mucosal nanoparticle flu vaccine using CRISPR-Cas to engineer bacteriophage T4, showing it induces both mucosal and systemic immunity in mice.

Serine proteinase inhibitors from Nicotiana benthamiana, a non-preferred host plant, inhibit the growth of Myzus persicae (green peach aphid)

The paper identifies three serine protease inhibitors from Nicotiana benthamiana that inhibit Myzus persicae growth and survival.

Trans-cellular control of synapse properties by a cell type-specific splicing regulator

This study identifies SLM2 as a cell type-specific splicing regulator that influences synaptic properties through trans-cellular control, leading to synaptic and memory defects when lost in specific neuronal populations.

A novel brain penetrant PDGFRα inhibitor HY-008 is effective against glioblastoma

This paper identifies HY-008, a PDGFRα inhibitor with high BBB permeability, as effective against glioblastoma in vitro and in vivo, showing improved survival and synergy with TMZ.

Horizontally transferred genes as RNA interference targets for aphid and whitefly control

This study identifies horizontally transferred genes (HTGs) in aphids and whiteflies as potential RNAi targets for pest control, showing they can be silenced without harming beneficial insects.

Treg cells drive MYCN-mediated immunosuppression and tumor aggressiveness in high-risk neuroblastoma

This study shows Treg cells drive MYCN-mediated immunosuppression and tumor aggressiveness in high-risk neuroblastoma using human and zebrafish models.

Analysis of sex differential genes at whole genome level reveals their organ- and chromosome-dependent expressions, regulations, and interactions

The paper analyzes sex differential genes across seven tissues in BXD mouse strains, revealing organ- and chromosome-dependent expression patterns and functional roles.

Structure-based prediction and characterization of photo-crosslinking in native protein-RNA complexes

The paper develops PxR3D-map to predict and characterize photo-crosslinking in protein-RNA complexes using structural data and crosslink site mapping.

A toxin-mediated policing system in Bacillus improves population fitness via penalizing non-cooperating phenotypic cheaters

This study identifies a toxin-mediated policing system in Bacillus that punishes phenotypic cheaters, enhancing population fitness in plant rhizosphere and under stress.

Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX

This study identifies a viral export signal in hepatitis A virus that requires dual recruitment of HD-PTP and ALIX for nonlytic release in extracellular vesicles.

Lifting the ban on nuclear import activates Gdown1-mediated modulation of global transcription and facilitates adaptation to cellular stresses

This study shows that nuclear import of Gdown1 modulates global transcription and enhances cellular stress tolerance.

Predicting plant-related and leaf-related parameters of winter wheat using vegetation index: Should phenological correction be applied across growth stages?

This study evaluates whether a unified model can predict plant and leaf parameters of winter wheat using vegetation indices across growing seasons, finding that hierarchical linear models (HLM) are stable and applicable across seasons for most parameters.

Novel MBLs inhibitors screened from FDA-approved drug library restore the susceptibility of carbapenems to NDM-1-harbouring bacteria

The paper screens FDA-approved drugs to find inhibitors of NDM-1, restoring carbapenem efficacy against resistant bacteria.

Assessment of AI-based Protein Structure Prediction for the NLRP3 Target

This study evaluates AI-based protein structure prediction for NLRP3, showing that AI models can generate reliable structures useful for small-molecule drug discovery.

Quorum sensing signal autoinducer-2 inhibits sporulation of Bacillus by interacting with RapC and functions across species

This study identifies AI-2 as a quorum sensing signal that inhibits sporulation in Bacillus velezensis SQR9 by interacting with RapC and ComA, revealing a population-level regulatory mechanism.

A unique genomic island-governed cannibalism in Bacillus enhanced biofilm formation through a novel regulation mechanism

This study identifies a novel cannibalism mechanism in Bacillus velezensis SQR9 mediated by bacillunoic acids, enhancing biofilm formation and interspecies competition through a two-component regulatory system.

The beneficial rhizobacterium Bacillus velezensis acquires iron from roots via a type VII secretion system for colonization

This study shows that Bacillus velezensis SQR9 uses a type VII secretion system to acquire iron from plant roots, enhancing its colonization.

Bacteriophage T4 Vaccine Platform for Next-generation Influenza Vaccine Development

This study demonstrates a T4 phage-based vaccine platform that incorporates M2e antigens, showing high immunogenicity and complete protection against influenza without adjuvants.

The volatile cedrene from plant beneficial Trichoderma guizhouense modulates Arabidopsis root development through auxin transport and signaling

AAV-Txnip prolongs cone survival and vision in mouse models of retinitis pigmentosa

This study identifies Txnip as a gene that prolongs cone photoreceptor survival and improves vision in retinitis pigmentosa mouse models.

Impact of nitrogen and phosphorus addition on resident soil and root mycobiomes in beech forests

This study examines how nitrogen and phosphorus fertilization affects soil and root mycobiomes in beech forests, finding shifts in fungal community composition and functional potential.

An acylsugar-deficient Nicotiana benthamiana strain for aphid and whitefly research

This paper generates an acylsugar-deficient Nicotiana benthamiana mutant to improve studies of plant-insect interactions and virus transmission.