S. Einav

PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2

RMC-113 inhibits PIP4K2C and PIKfyve, reversing SARS-CoV-2-induced autophagic flux impairment and showing antiviral effects.

Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity

The paper optimizes a 2-aminopyrimidine-based macrocycle to create a dual EPHA2/GAK kinase inhibitor with antiviral activity against dengue virus.

Single B cell transcriptomics identifies multiple isotypes of broadly neutralizing antibodies against flaviviruses

The paper uses single-cell transcriptomics to identify new broadly neutralizing antibodies against flaviviruses, including an IgA1 isotype with unique neutralizing properties.

Design of SARS-CoV-2 protease inhibitors with improved affinity and reduced sensitivity to mutations

This study designs a SARS-CoV-2 protease inhibitor with improved affinity and reduced mutation sensitivity compared to existing drugs.

Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans

The paper identifies conserved antiviral pathways across macaques and humans using transcriptomic data from viral infections, showing shared and virus-specific responses that inform pandemic preparedness.

Global and cell type-specific immunological hallmarks of severe dengue progression

This study identifies DENV target cells and immunological changes in severe dengue progression using single-cell RNA-Seq and functional assays in children.

Magnitude and kinetics of the human immune cell response associated with severe dengue progression by single-cell proteomics

The paper uses single-cell proteomics to analyze immune cell responses in severe dengue patients, identifying distinct immune dynamics compared to uncomplicated dengue.

Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX

This study identifies a viral export signal in hepatitis A virus that requires dual recruitment of HD-PTP and ALIX for nonlytic release in extracellular vesicles.

Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for therapy

This study shows that Numb-associated kinases are essential for SARS-CoV-2 infection and that inhibiting them can suppress viral infection in human lung cells.

Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen

This study identifies lapatinib, an ErbB inhibitor, as a broad-spectrum antiviral that suppresses SARS-CoV-2 and VEEV replication, inflammation, and lung injury through ErbB-mediated mechanisms.

Inflated citations and metrics of journals discontinued from Scopus for publication concerns: the GhoS(t)copus Project

This study analyzes citation metrics of journals removed from Scopus for publication concerns, finding increased citations post-removal and prevalence of predatory practices.

The transcriptional landscape of Venezuelan equine encephalitis virus (TC-83) infection

This study uses single-cell RNA sequencing to analyze the host and viral RNA dynamics during VEEV infection, identifying superproducer cells and candidate antiviral targets.

Functional characterization and lineage analysis of broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics

The paper identifies two broadly neutralizing antibodies against dengue virus through single B cell transcriptomics and characterizes their epitopes and evolutionary pathways.

Virus-inclusive single cell RNA sequencing reveals molecular signature predictive of progression to severe dengue infection

This study uses single-cell RNA sequencing to identify molecular signatures predictive of severe dengue infection by analyzing PBMCs from dengue patients and healthy controls.

Single-cell transcriptional dynamics of flavivirus infection

This study introduces viscRNA-Seq to analyze virus-host interactions at the single-cell level, revealing host factors specific to dengue and Zika virus infections.