Author

A. Hesin

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Cell Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1

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J. Yaglom· 1 shared M. Y. Sherman· 1 shared S. Kumar· 1 shared S. Patel· 1 shared

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2021-2021 · peak 1/yr

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1 shared paperCell Biology

J. Yaglom

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1 paper

Recent·Most cited

Cell BiologybioRxivApr 13, 2021

eIF2α integrates proteotoxic signals both from ER and cytoplasm: Hsp70-Bag3 module regulates HRI-dependent phosphorylation of eIF2α

S. Patel, S. Kumar, A. Hesin…·M. Y. Sherman

The paper shows that JG-98, an Hsp70 inhibitor, causes cell death by activating the eIF2α phosphorylation pathway through the Hsp70-Bag3 complex, linking ER and cytoplasmic proteotoxicity.

DOI 10.1016/j.isci.2022.104282

humanbulk RNA-seq

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