B. Zheng

Osteoclast-Cancer Cell Metabolic Symbiosis Renders PARP Inhibitor Therapy Resistance in Bone Metastasis

This study identifies a metabolic symbiosis between osteoclasts and cancer cells in bone metastasis that contributes to PARP inhibitor resistance, showing that targeting this interaction with PARPi and zoledronate can synergistically reduce metastasis.

Lymphotoxin-β Promotes Bone Colonization and Osteolytic Outgrowth of Indolent Bone Metastatic cells of Breast Cancer

This study identifies lymphotoxin-β as a key factor promoting bone colonization and osteolytic outgrowth of breast cancer metastatic cells.

22kHz Ultrasonic Vocalizations and Body Freezing May Represent Two Systems of Fear in Rodent Fear Conditioning Paradigms

This study investigates two fear responses in rodents, finding that 22kHz ultrasonic vocalizations reflect subjective fear while body freezing indicates an automatic defensive response.

Dichotomy of neutralizing antibody, B cell and T cell responses to SARS-CoV-2 vaccination and protection in healthy adults

The paper identifies four patterns of SARS-CoV-2 vaccine responses, including broad and narrow responders, and links broad responder traits to longer infection-free time after vaccination.

An Empirical Study on the Motivation of Helping Behavior in Rats

This study investigates the motivations for helping behavior in rats through three experiments, finding that social contact and environmental interest are primary motivators, while distress alleviation and prior social experience influence behavior onset and persistence.

Chromosome-level genomes of multicellular algal sisters to land plants illuminate signaling network evolution

The paper sequenced four Zygnematophyceae algal genomes to study signaling network evolution, finding expanded genes for multicellularity and environmental response.

S373P Mutation Stabilizes the Receptor-binding Domain of Spike Protein in Omicron and Promotes Binding

The paper investigates the effect of the S373P mutation on the stability and binding ability of the Omicron spike protein's RBD using AFM-SMFS and molecular dynamics simulations.

Mutation N501Y in RBD of Spike Protein Strengthens the Interaction between COVID-19 and its Receptor ACE2

This study investigates how the N501Y mutation in the SARS-CoV-2 spike protein's RBD enhances its binding to ACE2, contributing to increased transmissibility of variants.

Comprehensive Analysis of Spatial Architecture in Primary Liver Cancer

This study constructs high-resolution spatial transcriptomes of primary liver cancers to analyze spatial architecture and identify tumor microenvironment features.

The Cdc42 GTPase activating protein Rga6 promotes the cortical localization of Septin

This study identifies Rga6 as a protein that promotes Septin complex localization to the cell cortex in fission yeast, supporting a model of polarized cell growth regulation.

Integration of APSIM and PROSAIL models to develop more precise radiometric estimation of crop traits using deep learning

This paper integrates crop growth and radiative transfer models with deep learning to improve the estimation of crop traits from hyperspectral data.

Adult porcine (Sus scrofa) derived inner ear cells possessing multipotent stem/progenitor cell characteristics in in vitro cultures

This study reports the successful in vitro culture of adult porcine inner ear cells that retain stem/progenitor cell characteristics, offering a model for studying human inner ear disorders.

20-HETE-promoted cerebral blow flow autoregulation is associated with enhanced α-smooth muscle actin positive cerebrovascular pericyte contractility

This study shows that 20-HETE enhances pericyte contractility and cerebral blood flow autoregulation in rats by modulating vascular smooth muscle cell function.

A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2

A cocktail of neutralizing antibodies targeting SARS-CoV-2 spike protein's NTD and RBD, when used as immunogens in rabbits, elicited strong protective immune responses.

An electrostatic-interaction-based mechanism triggering misfolding of prion proteins from cellular isoform to scrapie isoform

This paper proposes an electrostatic-interaction-based mechanism for prion protein refolding from PrPC to PrPSc, identifying key steps involving hydrophobic interactions and pH changes.

eIF5a reduction via decreased Klf5 leads to cell senescence by mitochondrial fission in VSMCs

This study shows that Klf5 downregulation in VSMCs leads to mitochondrial fission and senescence by reducing eIF5a, which preserves mitochondrial integrity.

A Strategy Study on Risk Communication of Pandemic Influenza ----A Mental Model Study of College Students in Beijing

This paper analyzes college students' risk perception of pandemic influenza in Beijing using mental model interviews and the Delphi method to identify key risk factors and improve risk communication strategies.

Circular RNAs regulate cancer stem cells by FMRP against CCAR1 complex in hepatocellular carcinoma

This study identifies circZKSCAN1 as a negative regulator of cancer stem cells in hepatocellular carcinoma, revealing its mechanism through interaction with FMRP and CCAR1-Wnt signaling.

A novel sialylation site on Neisseria gonorrhoeae lipooligosaccharide links heptose II lactose expression with pathogenicity

This paper identifies a novel sialylation site on Neisseria gonorrhoeae lipooligosaccharide that links HepII lactose expression with pathogenicity and vaccine potential.