Endoplasmic reticulum associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity
L. Liu, A. Inoki, K. Fan, F. Mao, G. Shi, X. Jin, M. Zhao, G. Ney, S. Sun, Y. Dou, K. Inoki, L. Qi, Q. Li
This study shows that ERAD preserves HSC quiescence and self-renewal by restricting mTOR activity, preventing HSC depletion and hyper-proliferation.
bioRxiv · Jul 21, 2019Cell Biology