L. Qi

Extracellular electron transfer drives efficient H2-independent methylotrophic methanogenesis by Methanomassiliicoccus, a seventh order methanogen

This study shows Methanomassiliicoccus uses extracellular electron transfer for efficient methylotrophic methanogenesis, enhancing methane production in coculture with electrogenic bacteria.

Genomic Mapping Reveals Cisplatin Disruption of Protein Phosphorylation Signalling Genome-Wide

This study identifies 16216 cisplatin-damaged genes in human lung cancer cells and shows cisplatin disrupts protein phosphorylation signalling by targeting 85% of protein kinase and 81% of phosphatase genes.

R-Loop Functions in Brca1-Associated Mammary Tumorigenesis

This study shows that reducing R-loops in Brca1-knockout mice increases ER-expressing tumors but does not affect tumor incidence.

IL-1beta-induced epithelial cell and fibroblast transdifferentiation fuels neutrophil recruitment in chronic rhinosinusitis with nasal polyps

This study identifies IL-1beta-induced cell subsets that promote neutrophil recruitment in CRSwNP and shows IL-1beta inhibition reduces inflammation.

Guanylate cyclase activity of TIR1/AFB auxin receptors mediates rapid auxin responses

The paper shows TIR1/AFB auxin receptors have both adenylate and guanylate cyclase activities, mediating transcriptional reprogramming and rapid Ca2+-dependent growth responses.

Rapid translocation of NGR proteins driving polarization of PIN-activating D6 protein kinase during root gravitropism

The paper visualizes NGR1 localization during root gravitropism and shows its role in facilitating rapid D6PK translocation to redirect auxin flux.

Microsporidia dressing up: the spore polaroplast transport through the polar tube and transformation into the sporoplasm membrane

This study investigates the formation of the sporoplasm membrane during microsporidia spore germination, revealing that the polaroplast transforms into the sporoplasm membrane via the polar tube.

SEL1L-HRD1 interaction is prerequisite for the formation of a functional HRD1 ERAD complex

This study shows that the SEL1L-HRD1 interaction is essential for HRD1 ERAD complex function, as its disruption leads to developmental defects and cerebellar ataxia in mice.

Myosin in autoinhibited off state(s), stabilized by mavacamten, can be recruited via inotropic effectors

This paper shows that mavacamten stabilizes myosin in off states, which can still be recruited by physiological inotropic effectors to maintain cardiac function.

Discovery and characterization of cross-reactive intrahepatic antibodies in severe alcoholic hepatitis

This study identifies cross-reactive intrahepatic antibodies in severe alcoholic hepatitis that target both bacterial antigens and human proteins, suggesting a role in disease pathogenesis.

Danicamtiv increases myosin recruitment and alters the chemomechanical cross bridge cycle in cardiac muscle

This study investigates how Danicamtiv increases force and alters cardiac muscle contraction kinetics by modulating myosin function and cross bridge dynamics in cardiac tissue.

Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover

The paper identifies SEL1L as a regulator of collagen turnover through a negative feedback loop, showing its role in limiting collagen accumulation in fibrotic lung disease.

Distinct functions of TIR1 and AFB1 receptors in auxin signalling

The paper compares the roles of TIR1 and AFB1 in transcriptional and rapid auxin responses, showing their distinct functions are due to specific protein properties, not subcellular localization.

Comprehensive investigation and regulatory function of lncRNAs engaged in western honey bee larval immune response to Ascosphaera apis invasion

This study identifies and analyzes lncRNAs in western honey bee larvae infected with Ascosphaera apis, revealing their regulatory roles in immune responses through transcriptome analysis and ceRNA network analysis.

Inactivation of Vascular Stem Cells Suppresses Intimal Hyperplasia in Vein Grafts

The paper identifies vascular stem cells (VSCs) as a novel target for treating chronic vein graft failure by promoting intimal hyperplasia through paracrine signaling.

Cardiac myosin filaments are directly regulated by calcium

This study shows that cardiac myosin filaments are directly regulated by calcium, transitioning from inactive to active states through structural changes.

Conserved and newly acquired roles of PIF1 homologs in tomato (Solanum lycopersicum)

This study examines PIF1 homologs in tomato, showing conserved and new roles compared to Arabidopsis, with PIF1a having additional functions in root hair elongation and fruit development.

An inactivated multivalent influenza A virus vaccine is broadly protective in mice and ferrets

This study shows an inactivated multivalent influenza A vaccine provides broad protection against diverse IAV subtypes in mice and ferrets, including non-vaccine strains, suggesting its potential as a universal vaccine.

Notch-Induced Endoplasmic Reticulum-Associated Degradation Governs Thymocyte β-Selection

This study identifies ERAD as a proteostasis checkpoint during β-selection, showing Sel1l deficiency causes ER stress and apoptosis, impairing β T cell development.

Annealing synchronizes the 70S ribosome into a minimum-energy conformation

This paper demonstrates that annealing the 70S ribosome at a fast cooling rate synchronizes it into a minimum-energy conformation, enhancing homogeneity and stability for structural analysis.

In vivo co-registered hybrid-contrast imaging by successive photoacoustic tomography and magnetic resonance imaging

This paper presents a hardware-software solution for co-registering photoacoustic tomography and MRI images in vivo, demonstrating hybrid-contrast imaging of tumor microenvironments.

Genome-Wide Mapping of Cisplatin Damaged Gene Loci

This study maps cisplatin-damaged gene loci and identifies key pathways and targets, revealing SPAG9 as a potential therapeutic target for testicular cancer.

Morphologic Classification and Automatic Diagnosis of Bacterial Vaginosisby Deep Neural Networks

This paper develops CNN models to automatically classify Nugent scores from vaginal microscopy images, achieving higher accuracy than human experts.

Comparative secretome of Magnaporthe oryzae identified proteins involved in virulence and cell wall integrity

This study compares the secretome of Magnaporthe oryzae wild type and Δalg3 mutants, identifying 51 proteins requiring ALG3 for secretion and showing their roles in virulence and cell wall integrity.

Cryo-EM Structure of the Human Mitochondrial Translocase TIM22 Complex

The paper reports the cryo-EM structure of the human TIM22 complex at 3.7 angstrom resolution, revealing its architecture and potential mechanism for protein import.

aCPSF1 controlled archaeal transcription termination: a prototypical eukaryotic model

This paper identifies aCPSF1 as the first general transcription termination factor in Archaea, revealing its cleavage-dependent termination mechanism and evolutionary relationship to eukaryotic processes.

Integrin α6β4 signaling switches DNA repair from homologous recombination to non-homologous end-joining pathway to sensitize breast cancer cells to cisplatin

This study shows integrin α6β4 signaling shifts DNA repair from homologous recombination to non-homologous end joining in TNBC, increasing sensitivity to cisplatin.

Endoplasmic reticulum associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity

This study shows that ERAD preserves HSC quiescence and self-renewal by restricting mTOR activity, preventing HSC depletion and hyper-proliferation.

Leptin deficient rats develop nonalcoholic steatohepatitis with unique disease progression

This study characterizes LepΔI14/ΔI14 rats as a NASH model through long-term transcriptomic analysis, revealing unique disease progression and gene expression patterns.

Elongator is required for root stem cell maintenance by regulating SHORT ROOT transcription

This study shows that Elongator regulates SHORT ROOT transcription in Arabidopsis roots, essential for stem cell maintenance and radial patterning.