Y. Dou

Loop-mediated Isothermal Amplification (LAMP) assay for reliable detection of Xanthomonas axonopodis pv. vasculorum

This paper develops a LAMP assay for detecting Xanthomonas axonopodis pv. vasculorum using the pelL gene, demonstrating high specificity and sensitivity for field use.

Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer

The paper shows that ZNRF3/RNF43 ubiquitinates and degrades EGFR, and their loss increases EGFR signaling, promoting cancer growth.

DNA sensor ABCF1 phase separates with cccDNA to inhibit HBV replication

This study identifies ABCF1 as a host protein that interacts with cccDNA, forming phase-separated condensates to suppress HBV replication through innate immune activation and transcription inhibition.

A generic binding pocket for small molecule IKs activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes

The paper identifies a generalized binding pocket for small molecule IKs activators at the extracellular interface of KCNQ1 and KCNE1 channel complexes, explaining their mechanism and guiding future drug design.

WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation

This study identifies WDR5 as an epigenetic regulator that promotes breast cancer growth and metastasis through KMT2-independent translation regulation, suggesting therapeutic strategies targeting WDR5.

MLL1 Methyltransferase Activity is Regulated by Distinct Nucleosome Binding Modes

The paper determines the cryoEM structure of the MLL1 complex bound to a nucleosome and identifies two binding modes, one of which is catalytically inactive.

BREVIPEDICELLUS and ERECTA mediate expression of AtPRX17 in preventing Arabidopsis callus retardation and browning

This study identifies BREVIPEDICELLUS and ERECTA pathways that prevent Arabidopsis callus browning by regulating AtPRX17 expression.

Adverse neurological effects of short-term sleep deprivation in aging mice are prevented bySS31 peptide

This study shows that SS31 peptide prevents learning impairment and restores mitochondrial function in aged mice after short-term sleep deprivation.

Mapping the Immunodominance Landscape of SARS-CoV-2 Spike Protein for the Design of Vaccines against COVID-19

This study maps immunodominant sites on the SARS-CoV-2 spike protein using patient sera to identify potential vaccine candidates and demonstrates their neutralizing activity in mice.

Affinity proteomic dissection of the human nuclear cap-binding-complex interactome

This study maps the human nuclear cap-binding complex interactome using affinity proteomics to clarify the composition and interactions of NCBP1, NCBP2, and NCBP3-related macromolecular assemblies.

KMT2D Links TGF-β Signalling to Non-Canonical Activin Pathway and Regulates Pancreatic Cancer Cell Plasticity

This study identifies KMT2D as a tumor suppressor in pancreatic cancer, linking TGF-β signaling to the non-canonical activin A pathway through miR-147b and showing its role in cancer cell plasticity and metastasis.

Microscaled Proteogenomic Methods for Precision Oncology

This study develops microscaled proteogenomic methods for cancer analysis, showing treatment response and resistance mechanisms in ERBB2-positive breast cancers.

Simultaneous Targeting of XPO1 and BCL2 as an Effective Treatment Strategy for Double-Hit Lymphoma

This study shows that combining XPO1 and BCL2 inhibitors effectively treats double-hit lymphoma by suppressing MYC and BCL2 oncogenes, reducing tumor growth and preventing metastasis.

Cryo-EM structure of the human Mixed Lineage Leukemia-1 complex bound to the nucleosome

The paper reports the cryo-EM structure of the human MLL1 complex bound to the nucleosome, revealing how it interacts with histone H3K4 and promotes tri-methylation.

Endoplasmic reticulum associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity

This study shows that ERAD preserves HSC quiescence and self-renewal by restricting mTOR activity, preventing HSC depletion and hyper-proliferation.