Author

A. J. Aguirre

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 3 Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

B. M. Wolpin· 2 shared J. M. McFarland· 2 shared K. S. Kapner· 2 shared A. A. Borah· 1 shared A. D. Cherniack· 1 shared A. DenAdel· 1 shared A. Dias Costa· 1 shared A. Gikandi· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

B. M. Wolpin

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 7, 2023

Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer

X. Tong, A. S. Patel, E. Kim…·H. Ji

The paper identifies adeno-to-squamous transition (AST) as a mechanism of resistance to KRAS inhibitors in LKB1 mutant lung cancer and links KRT6A expression to poor patient outcomes.

DOI 10.1101/2023.09.07.556567

mousebulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintAug 25, 2020

The tumor microenvironment drives transcriptional phenotypes and their plasticity in metastatic pancreatic cancer

S. Raghavan, P. S. Winter, A. W. Navia…·A. K. Shalek

This study identifies a transitional cancer cell state in metastatic pancreatic cancer and shows that tumor microenvironment signals drive transcriptional plasticity and subtype transitions.

DOI 10.1101/2020.08.25.256214

humanscRNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivDec 8, 2019

Multiplexed single-cell profiling of post-perturbation transcriptional responses to define cancer vulnerabilities and therapeutic mechanism of action

J. M. McFarland, B. R. Paolella, A. Warren…·A. Tsherniak

The paper introduces MIX-Seq, a method for multiplexed single-cell transcriptional profiling of cancer cell responses to perturbations, revealing drug mechanisms and predicting cell viability.

DOI 10.1038/s41467-020-17440-w

humanscRNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivSep 14, 2019

Defining and targeting adaptations to oncogenic KRASG12C inhibition using quantitative temporal proteomics

N. Santana-Codina, A. S. Chandhoke, Q. Yu…·J. D. Mancias

This study uses quantitative temporal proteomics to analyze KRASG12C inhibitor responses in cancer models, identifying effective drug combinations to overcome resistance.

DOI 10.1016/j.celrep.2020.03.021

humanproteomics

𝕏 PostBluesky