A. Warren

eIF6 rebinding dynamically couples ribosome maturation and translation

This study shows eIF6 dynamically couples ribosome maturation and translation by sequestering 60S subunits, and its disruption impairs erythropoiesis in mice.

Phosphate dysregulation via the XPR1:KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer

The paper identifies XPR1 and KIDINS220 as therapeutic targets in ovarian cancer by showing their role in phosphate dysregulation leading to cell death.

The latitudinal diversity gradient in brush-footed butterflies (Nymphalidae): conserved ancestral tropical niche but different continental histories.

This study evaluates hypotheses for the latitudinal diversity gradient in Nymphalidae butterflies, finding that low extinction rates and historical dispersal patterns, rather than speciation rates, explain diversity patterns.

Global computational alignment of tumor and cell line transcriptional profiles

The paper develops an unsupervised alignment method to compare tumor and cell line transcriptional profiles, revealing differences in similarity across cancer types and identifying cell lines with distinct transcriptional states.

Cellular mRNA signals in human kidney tumors

This study analyzes mRNA signals in 1,300 kidney tumors to determine their differentiation state and origin, finding that childhood tumors show fetal signals while most adult tumors do not, with exceptions in certain cancer types.

Gene expression has more power for predicting in vitro cancer cell vulnerabilities than genomics

This study compares DNA- and expression-based models for predicting cancer cell viability and finds expression models are more accurate and interpretable.

Multiplexed single-cell profiling of post-perturbation transcriptional responses to define cancer vulnerabilities and therapeutic mechanism of action

The paper introduces MIX-Seq, a method for multiplexed single-cell transcriptional profiling of cancer cell responses to perturbations, revealing drug mechanisms and predicting cell viability.

Independence of HIF1a and androgen signaling pathways in prostate cancer

The paper investigates the relationship between HIF1a and androgen signaling pathways in prostate cancer, finding they operate independently and identify shared genes associated with poor prognosis.

Pan-cancer single cell RNA-seq uncovers recurring programs of cellular heterogeneity

The paper uses single-cell RNA-seq to analyze cancer cell lines and identifies recurring expression programs of heterogeneity that mirror those in tumors, suggesting intrinsic plasticity contributes to intra-tumoral diversity.

Direct measurement of X-ray induced heating of microcrystals

The paper quantifies X-ray induced heating of microcrystals by measuring temperature-dependent shifts in X-ray induced fluorescence from ruby crystals.

Habitat heterogeneity drives scale-dependent biodiversity loss in a temperate marine ecosystem

The paper examines how local habitat heterogeneity influences biodiversity loss in kelp beds affected by climate stressors over two decades.