A. J. Roe

AdhE spirosome length in enterohaemorrhagic Escherichia coli is correlated with enzymatic directionality and is perturbed by salicylidene acylhydrazide binding

This paper shows that ME0054 disrupts AdhE spirosomes, enhancing ethanol-to-acetyl-CoA conversion and altering T3SS expression in EHEC.

Enhancing a multipurpose artificial urine for culture and gene expression studies of uropathogenic Escherichia coli strains

This study enhances an artificial urine medium to support growth of UPEC strains and shows similar gene expression profiles compared to pooled human urine.

The therapeutic potential of D-Serine in reducing expression of the cytopathic genotoxin colibactin

This study shows D-Serine reduces colibactin expression and cytopathic effects in E. coli strains, suggesting its therapeutic potential for preventing colibactin-related diseases.

Propionic acid promotes the virulent phenotype of Crohns disease-associated adherent-invasive Escherichia coli

This study shows that propionic acid exposure increases virulence in adherent-invasive Escherichia coli, leading to higher persistence in mice and altered gene expression.

A highly conserved complete accessory Escherichia coli type III secretion system 2 is widespread in bloodstream isolates of the ST69 lineage

The paper identifies that E. coli ST69 bloodstream isolates contain an intact ETT2 locus, suggesting functional importance in infection despite no identified secreted substrates.