M. Connor

Activation of cannabinoid CB2 receptors by (-)-cannabichromene but not (+)-cannabichromene

This study shows that (-)-cannabichromene activates CB2 receptors, while (+)-cannabichromene does not, and both activate TRPA1.

Disease-attenuated pneumococcal biosynthesis gene mutants invade the mucosal epithelium and induce innate immunity

This paper shows that disease-attenuated pneumococcal mutants retain epithelial microinvasion but show reduced transmigration and altered inflammatory responses.

Modulation of Recombinant Human T-type calcium channels by Δ9-tetrahydrocannabinolic acid in vitro

This study investigates the effects of THCA on T-type calcium channels in vitro, finding it modulates channel kinetics and voltage dependence without psychoactive effects.

Modulation of Human T-type Calcium Channels by Synthetic Cannabinoid Receptor Agonists in vitro

This study investigates how synthetic cannabinoid receptor agonists modulate human T-type calcium channels, finding potent inhibition and suggesting a potential mechanism for their toxicity.

Streptococcus pneumoniae infection promotes histone H3 dephosphorylation by modulating host PP1 phosphatase

This study shows Streptococcus pneumoniae infection causes histone H3 dephosphorylation at serine 10 via host PP1 phosphatase activation, enhancing bacterial survival.

Differential activation of G protein-mediated signalling by synthetic cannabinoid receptor agonists

This study compares how synthetic cannabinoid receptor agonists activate Gs and Gi/o proteins, finding differences in their potency and rank order for cAMP stimulation and inhibition.

Brodifacoum does not modulate human cannabinoid receptor-mediated hyperpolarization of AtT20 cells or inhibition of adenylyl cyclase in HEK 293 cells

This paper investigates whether brodifacoum affects cannabinoid receptor function in cells and finds it does not modulate receptor-mediated hyperpolarization or adenylyl cyclase inhibition.

Absence of entourage: Terpenoids commonly found in Cannabis sativa do not modulate the functional activity of Δ9-THC at human CB1 and CB2 receptors

This study tests whether common Cannabis terpenoids modulate CB1 and CB2 receptor activity in vitro, finding no significant effect on receptor signaling or desensitization.

Cannabichromene is a cannabinoid CB2 receptor agonist

This study identifies cannabichromene (CBC) as a selective CB2 receptor agonist with higher efficacy than THC in hyperpolarizing AtT20 cells.

The chemistry and pharmacology of putative synthetic cannabinoid receptor agonist (SCRA) new psychoactive substances (NPS) 5F-PY-PICA, 5F-PY-PINACA, and their analogues

This study synthesizes and characterizes new psychoactive substances (NPS) and evaluates their pharmacology at cannabinoid receptors.

A highly conserved complete accessory Escherichia coli type III secretion system 2 is widespread in bloodstream isolates of the ST69 lineage

The paper identifies that E. coli ST69 bloodstream isolates contain an intact ETT2 locus, suggesting functional importance in infection despite no identified secreted substrates.

In vitro determination of the CB1 efficacy of illicit synthetic cannabinoids

This study evaluates the efficacy of 13 synthetic cannabinoids at the CB1 receptor using receptor depletion and operational model fitting, finding most have higher efficacy than Δ9-THC.