D. M. Wall

Characterisation of prophages in Clostridium clostridioforme: an understudied component of the intestinal microbiome

This study characterizes prophages in Clostridium clostridioforme LM41, identifying 15 prophages and their potential roles in host fitness and genetic diversity.

Microbiome-derived metabolite effects on intestinal barrier integrity and immune cell response to infection

This study investigates how gut microbiome-derived metabolites affect intestinal barrier integrity and immune cell responses to infection at the cellular level.

Genomic diversity of novel strains of mammalian gut microbiome derived Clostridium XIVa strains is driven by mobile genetic element acquisition

The paper isolates and characterizes novel Clostridium XIVa strains from the murine gut, revealing genomic diversity driven by mobile genetic element acquisition and expanded biosynthetic potential.

Stratifying macrophages based on their infectious burden identifies novel host targets for intervention during Crohns disease associated adherent-invasive Escherichia coli infection

The paper identifies novel therapeutic targets for AIEC infection by stratifying macrophages based on bacterial load and showing that targeting these pathways reduces AIEC replication.

Inhibition of proline tyrosine kinase 2 (Pyk2) phosphorylation during adherent-invasive Escherichia coli infection inhibits intra-macrophage replication and inflammatory cytokine release

This study shows that inhibiting Pyk2 reduces AIEC replication in macrophages and inflammatory cytokine release, suggesting a potential therapeutic target for Crohn's Disease.

Microbiome-derived metabolites reproduce the mitochondrial dysfunction and decreased insulin sensitivity observed in type 2 diabetes

The paper identifies two microbiome-derived metabolites, 3M-4-TMAB and 4-TMAP, that induce mitochondrial dysfunction and reduced insulin sensitivity in human liver cells, linking gut microbiota to type 2 diabetes.

Regulatory T cells control the dynamic and site-specific polarization of CD4 T cells following Salmonella infection

This study shows that FoxP3+ regulatory T cells (Tregs) dynamically influence CD4 T cell polarization during Salmonella infection, shifting from suppressing Th17 to Th1 responses over time.

Monocytes mediate Salmonella Typhimurium-induced tumour growth inhibition

This study shows that Salmonella Typhimurium SL7207 inhibits melanoma growth by recruiting pro-inflammatory monocytes, and blocking these monocytes reverses the anti-tumor effect.

Mapping the influence of the gut microbiota on small molecules in the brain through mass spectrometry imaging

This study uses mass spectrometry imaging to map microbial and host metabolites in the gut and brain of mice, finding altered metabolites in germ-free animals but not after antibiotic treatment.

Propionic acid promotes the virulent phenotype of Crohns disease-associated adherent-invasive Escherichia coli

This study shows that propionic acid exposure increases virulence in adherent-invasive Escherichia coli, leading to higher persistence in mice and altered gene expression.