BiophysicsbioRxiv
Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure
K. M. R. Faysal, J. C. Walsh, N. Renner…·T. Boecking
This study shows Lenacapavir's antiviral effect comes from hyperstabilizing the HIV-1 capsid lattice, leading to loss of compartmentalization and capsid failure.
DOI 10.7554/elife.83605