L. James

Recruitment of FBXO22 for Targeted Degradation of NSD2

This paper describes a targeted protein degradation strategy using UNC8732 to recruit FBXO22 for NSD2 degradation, leading to growth suppression and reversal of drug resistance in leukemia cells.

CTCF is essential for proper mitotic spindle structure and anaphase segregation

This study shows that CTCF is crucial for correct mitotic spindle structure and anaphase segregation, leading to abnormal nuclear morphology in interphase.

Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure

This study shows Lenacapavir's antiviral effect comes from hyperstabilizing the HIV-1 capsid lattice, leading to loss of compartmentalization and capsid failure.

TRIM7 restricts Coxsackievirus and norovirus infection by detecting the C-terminalglutamine generated by 3C protease processing

The paper identifies TRIM7 as a viral restriction factor that recognizes a conserved C-terminal glutamine motif generated by viral proteases, inhibiting Coxsackie and norovirus replication.

SARS-CoV-2 Omicron spike mediated immune escape, infectivity and cell-cell fusion

This study investigates the immune escape, infectivity, and cell-cell fusion properties of SARS-CoV-2 Omicron BA.1 compared to Delta, showing higher ACE2 affinity and antibody evasion but similar antiviral drug efficacy.

PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma

This study identifies PHGDH as essential for germinal center formation and shows its inhibition reduces lymphoma progression and improves survival.

Cross-tissue immune cell analysis reveals tissue-specific adaptations and clonal architecture across the human body

The paper analyzes immune cell diversity across 15 human tissues using single-cell RNA sequencing and VDJ sequencing, revealing tissue-specific features and clonal architecture of T and B cells.

Pharmacological targeting of a PWWP domain demonstrates cooperative control of NSD2 localization

The paper develops a chemical probe, UNC6934, that targets the PWWP1 domain of NSD2, revealing cooperative control of NSD2 localization through chromatin reader domains.

Recurrent emergence and transmission of a SARS-CoV-2 Spike deletion H69/V70

This paper identifies a recurrent SARS-CoV-2 Spike deletion (H69/V70) that increases infectivity and compensates for RBD mutations, suggesting it may facilitate immune escape and variant emergence.

Deep sequencing of B cell receptor repertoires from COVID-19 patients reveals strong convergent immune signatures

The paper analyzes B cell receptor repertoires from COVID-19 patients to identify convergent immune signatures associated with disease outcome.

Distinct microbial and immune niches of the human colon

The paper examines microbial and immune cell interactions in the human colon, identifying distinct immune niches and T cell profiles along the colon.

Functional characterization of genes mediating cell wall metabolism and responses to plant cell wall integrity impairment

The paper identifies genes involved in cell wall metabolism and responses to cell wall integrity impairment in Arabidopsis thaliana using T-DNA insertions and FTIR analysis.