Author

D. A. Jacques

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Approach:experimental assay· 2 Assay:fluorescence / live-cell microscopy· 1 Approach:microscopy & imaging analysis· 1 Organism:virus· 1

Frequent Co-Authors

A. Tuckwell· 2 shared C. F. Dickson· 2 shared E. Sierecki· 2 shared G. J. Towers· 2 shared J. C. Walsh· 2 shared S. G. Turville· 2 shared T. Boecking· 2 shared V. Shah· 2 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersBiochemistry

A. Tuckwell

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Author profile →

3 papers

Recent·Most cited

Karyopherin mimicry explains how the HIV capsid penetrates nuclear pores

C. F. Dickson, S. Hertel, J. Ruan, N. Ariotti, A. Tuckwell, N. Li, S. Al-Izzi, E. Sierecki, Y. Gambin, R. G. Morris, G. J. Towers, T. Boecking, D. A. Jacques

This paper shows how the HIV capsid mimics karyopherins to penetrate nuclear pores by interacting with FG-motifs, enabling it to bypass the size limit of the nuclear pore complex.

bioRxiv · Mar 23, 2023 · PreprintBiochemistry

Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure

K. M. R. Faysal, J. C. Walsh, N. Renner, C. L. Marquez, V. Shah, A. J. Tuckwell, M. P. Christie, M. W. Parker, S. G. Turville, L. James, G. J. Towers, D. A. Jacques, T. Boecking

This study shows Lenacapavir's antiviral effect comes from hyperstabilizing the HIV-1 capsid lattice, leading to loss of compartmentalization and capsid failure.

bioRxiv · Sep 21, 2022Biophysics

Rapid HIV-1 capsid interaction screening using fluorescence fluctuationspectroscopy

D. Lau, J. C. Walsh, C. F. Dickson, A. Tuckwell, J. H. Stear, D. J. B. Hunter, A. Bhumkar, V. Shah, S. G. Turville, E. Sierecki, Y. Gambin, D. A. Jacques, T. Böcking

This paper develops a fluorescence fluctuation spectroscopy method to rapidly screen HIV-1 capsid interactors by detecting binding events in solution.

bioRxiv · Nov 13, 2020Biophysics