Author

A. Jongejan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 3 Cancer Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Organism:human· 6 Approach:experimental assay· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Assay:scRNA-seq· 2 Organism:C. elegans· 1

Frequent Co-Authors

P. D. Moerland· 4 shared A. E. Neele· 2 shared F. J. Bemelman· 2 shared G. E. Janssens· 2 shared J. W. van der Heijden· 2 shared L. Vogt· 2 shared M. L. Hilhorst· 2 shared Y. Vegting· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersImmunology

P. D. Moerland

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Infiltrative classical monocyte-derived and SPP1 lipid-associated macrophages mediate inflammation and fibrosis in ANCA-associated glomerulonephritis

Y. Vegting, A. Jongejan, A. E. Neele, N. Claessen, G. Sela, K. H. Prange, J. Kers, J. J. Roelofs, J. W. van der Heijden, O. J. de Boer, E. B. Remmerswaal, L. Vogt, F. J. Bemelman, M. P. de Winther, P. D. Moerland, M. L. Hilhorst

This paper identifies specific macrophage subsets in ANCA-associated glomerulonephritis that drive inflammation and fibrosis, suggesting therapeutic targets.

bioRxiv · Mar 13, 2024 · PreprintImmunology

Cardiovascular risk in ANCA-associated vasculitis: monocyte phenotyping reveals distinctive signatures between serological subsets

Y. Vegting, K. M. Hanford, A. Jongejan, G. R. Gajadin, M. Versloot, N. D. van der Bom-Baylon, T. Dekker, E. L. Penne, J. W. van der Heijden, E. Houben, F. J. Bemelman, A. E. Neele, P. D. Moerland, L. Vogt, J. Kroon, M. L. Hilhorst

This study identifies distinct monocyte phenotypes and gene expression patterns in ANCA-associated vasculitis serotypes, linking them to cardiovascular risk.

bioRxiv · Jan 16, 2024Immunology

Treatment with a selective histone deacetylase (HDAC) 1 and 2 inhibitor in aged mice rejuvenates multiple organ systems

A. Tammaro, E. G. Daniels, I. M. Hu, K. C. t Hart, K. Reid, R. P. Juni, L. Butter, G. Vasam, R. S. Kamble, A. Jongejan, R. I. Aviv, J. J. T. H. Roelofs, E. Aronica, R. A. Boon, K. J. Menzies, , G. E. Janssens

This paper identifies a selective HDAC1/2 inhibitor, Cmpd60, that rejuvenates multiple organ systems in aged mice through transcriptional effects mimicking genetic longevity interventions.

bioRxiv · Aug 29, 2023 · PreprintPathology

Identification and mapping of human lymph node stromal cell subsets by combining single-cell RNA sequencing with spatial transcriptomics.

C. Grasso, J. Roet, C. Gago de Graca, J. F. Semmelink, E. Remmerswaal, A. Jongejan, P. D. Moerland, R. E. Mebius, L. G. M. van Baarsen

The paper identifies and maps human lymph node stromal cell subsets using scRNA-seq and spatial transcriptomics, revealing their spatial distribution and potential interactions with lymphocytes.

bioRxiv · Aug 18, 2023Cell Biology

A public antibody class recognizes a novel S2 epitope exposed on open conformations of SARS-CoV-2 spike

M. Claireaux, T. G. Caniels, M. de Gast, J. Han, D. Guerra, G. Kerster, B. D. van Schaik, A. Jongejan, A. I. Schriek, M. Grobben, P. J. Brouwer, K. van der Straten, Y. Aldon, J. Capella-Pujol, J. L. Snitselaar, , M. J. van Gils

The paper identifies a novel S2 epitope recognized by a public antibody class in SARS-CoV-2-reactive B cells, which becomes exposed on vaccine-optimized spike proteins.

bioRxiv · Dec 1, 2021Immunology

Reduced ech-6 Expression Attenuates Fat-induced Premature Aging in C. elegans

Y. J. Liu, A. W. Gao, R. L. Smith, G. E. Janssens, D. M. Panneman, A. Jongejan, M. van Weeghel, F. M. Vaz, M. J. Silvestrini, L. R. Lapierre, A. W. MacInnes, R. H. Houtkooper

This study shows that reducing ech-6 expression in C. elegans mitigates fat-induced premature aging, suggesting a role for ech-6 in metabolic flexibility and longevity.

bioRxiv · Nov 2, 2020 · PreprintCell Biology

Framing the potential of public frameshift peptides as immunotherapy targets in colon cancer

I. T. Spaanderman, F. S. Peters, A. Jongejan, E. J. Redeker, C. J. A. Punt, A. D. Bins

The paper identifies 20 frameshift peptides in MSI colon cancer patients that could serve as immunotherapy targets, covering most patients and Lynch syndrome cases.

bioRxiv · Mar 26, 2020Cancer Biology

Distinct prophase arrest mechanisms in human male meiosis

S. Z. Jan, A. Jongejan, C. M. Korver, S. K. M. van Daalen, A. M. M. van Pelt, S. Repping, G. Hamer

The paper identifies two distinct meiotic arrest mechanisms in human male meiosis leading to azoospermia and infertility.

bioRxiv · Sep 28, 2017Cell Biology