PathologybioRxivPreprint
Treatment with a selective histone deacetylase (HDAC) 1 and 2 inhibitor in aged mice rejuvenates multiple organ systems
A. Tammaro, E. G. Daniels, I. M. Hu…·G. E. Janssens
This paper identifies a selective HDAC1/2 inhibitor, Cmpd60, that rejuvenates multiple organ systems in aged mice through transcriptional effects mimicking genetic longevity interventions.
DOI 10.1101/2023.08.29.555280