Author

M. de Gast

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:non-human primate· 1 Assay:proteomics· 1

Frequent Co-Authors

G. Kerster· 2 shared I. Bontjer· 2 shared J. A. Burger· 2 shared J. D. Allen· 2 shared J. L. Torres· 2 shared K. Sliepen· 2 shared K. van der Straten· 2 shared M. Brinkkemper· 2 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersImmunology

G. Kerster

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ImmunologybioRxivDec 1, 2021

A public antibody class recognizes a novel S2 epitope exposed on open conformations of SARS-CoV-2 spike

M. Claireaux, T. G. Caniels, M. de Gast…·M. J. van Gils

The paper identifies a novel S2 epitope recognized by a public antibody class in SARS-CoV-2-reactive B cells, which becomes exposed on vaccine-optimized spike proteins.

DOI 10.1038/s41467-022-32232-0

humanflow cytometry

𝕏 PostBluesky

MicrobiologybioRxivNov 30, 2020

Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles

P. J. M. Brouwer, A. Antanasijevic, M. de Gast…·R. W. Sanders

This study shows that displaying HIV-1 Env trimers on two-component protein nanoparticles enhances autologous Tier-2 neutralizing antibody titers in rabbits.

DOI 10.1038/s41541-021-00285-9

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

ImmunologybioRxivNov 7, 2020

Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

P. J. M. Brouwer, M. Brinkkemper, P. Maisonnasse…·de Bree

This paper develops a two-component spike nanoparticle vaccine that protects macaques from SARS-CoV-2 infection by inducing strong neutralizing antibodies and reducing viral replication.

DOI 10.1016/j.cell.2021.01.035

non-human primateexperimental assay

𝕏 PostBluesky