Author

R. L. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Bioengineering· 1 Ecology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 5 Organism:human· 3 Organism:C. elegans· 2 Research Focus:host-pathogen & immune response· 2 Assay:metabolomics· 2 Assay:metagenomics· 2 Organism:mouse· 2

Frequent Co-Authors

A. W. Gao· 2 shared F. M. Vaz· 2 shared G. E. Janssens· 2 shared M. van Weeghel· 2 shared R. H. Houtkooper· 2 shared A. C. Luyf· 1 shared A. d. S. Moreira· 1 shared A. H. C. van Kampen· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersCell Biology

A. W. Gao

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Microbiomes of blood feeding triatomines in the context of their predatory relatives and the environment

H. Tarabai, A. M. Floriano, J. Zima, N. Filova, J. J. Brown, W. Roachell, R. L. Smith, N. L. Beatty, K. J. Vogel, E. Novakova

This study analyzes microbiomes of blood-feeding triatomines and their predatory relatives, identifying three bacterial sources and highlighting phylosymbiosis in Triatoma species.

Microbiology Spectrum · Aug 17, 2023Peer-reviewedEcology

Transdermal Electrophysiological Recordings of Diabetic Small Fiber Peripheral Neuropathy Using a Needle Electrode Array in Mice and Men

M. Blaszkiewicz, L. Caron, B. Villinski, J. Passarelli, J. Donnelly, J. M. Towne, N. M. Story, E. Merchant, F. S. Khan, N. Emanetoglu, L. Kass, R. L. Smith, K. L. Townsend

This paper introduces a novel transdermal device, DEN, for recording small fiber nerve activity in mice and humans, validated for detecting diabetic peripheral neuropathy.

bioRxiv · Mar 3, 2023 · PreprintBioengineering

Annexin A2 modulates phospholipid membrane composition upstream of Arp2 to control angiogenic sprout initiation

T. M. Sveeggen, C. A. Abbey, R. L. Smith, K. J. Bayless

This study identifies Annexin A2's role in modulating phospholipid composition to regulate F-actin and Arp2 dynamics, essential for angiogenic sprout initiation and maturation.

bioRxiv · Jul 7, 2022Cell Biology

Within-host evolutionary dynamics and tissue compartmentalization during acute SARS-CoV-2 infection

M. Farjo, K. Koelle, M. A. Martin, L. L. Gibson, K. K. Walden, G. Rendon, C. J. Fields, F. Alnaji, N. Gallagher, C. H. Luo, H. H. Mostafa, Y. C. Manabe, A. Pekosz, R. L. Smith, D. D. McManus, C. B. Brooke

This study uses daily saliva and nasal samples to track SARS-CoV-2 genetic variants in infected individuals, revealing stochastic evolution, mutational hotspots, and compartmentalization between sample sites.

bioRxiv · Jun 21, 2022Microbiology

Oral Lisinopril Raises Tissue Levels of ACE2, the SARS-CoV-2 Receptor, in Healthy Male and Female Mice

S. D. Brooks, R. L. Smith, A. d. S. Moreira, H. Ackerman

This study shows oral lisinopril increases ACE2 levels in multiple tissues of mice, while combining it with losartan prevents this increase and reduces Ace2 gene expression.

bioRxiv · Oct 19, 2021Pharmacology & Toxicology

Reduced ech-6 Expression Attenuates Fat-induced Premature Aging in C. elegans

Y. J. Liu, A. W. Gao, R. L. Smith, G. E. Janssens, D. M. Panneman, A. Jongejan, M. van Weeghel, F. M. Vaz, M. J. Silvestrini, L. R. Lapierre, A. W. MacInnes, R. H. Houtkooper

This study shows that reducing ech-6 expression in C. elegans mitigates fat-induced premature aging, suggesting a role for ech-6 in metabolic flexibility and longevity.

bioRxiv · Nov 2, 2020 · PreprintCell Biology

Metabolomics and lipidomics in C. elegans using a single sample preparation

M. Molenaars, B. V. Schomakers, H. L. Elfrink, A. W. Gao, M. A. T. Vervaart, M. L. Pras-Raves, A. C. Luyf, R. L. Smith, M. G. Sterken, J. E. Kammenga, A. H. C. van Kampen, G. E. Janssens, F. M. Vaz, M. van Weeghel, R. H. Houtkooper

This paper introduces a single-sample preparation method for comprehensive metabolomics and lipidomics in C. elegans, enabling semi-quantitative analysis of over 100 polar metabolites and over 1000 apolar metabolites.

bioRxiv · Jul 6, 2020Biochemistry