Linking collective migration/growth to differentiation boosts global shaping of the transcriptome and exhibits a grasshopper effect for driving maturation
O. Ogoke, D. Guiggey, A. Chiang, S. Thompson, T. H. A. Nguyen, D. Berke, C. Ott, A. Kalinousky, C. Shamul, P. Chen, S. Ross, Z. Chen, P. Srivastava, C. Gaughan, S. D. Mahajan, , N. Parashurama
The paper links collective migration to differentiation in hPSC-derived hepatocytes, showing a significant increase in maturation through a deep-learning gene circuit.
bioRxiv · Jul 24, 2022 · PreprintBioengineering