Author

D. Guiggey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

A. Chiang· 2 shared N. Parashurama· 2 shared O. Ogoke· 2 shared P. Chen· 2 shared S. Thompson· 2 shared A. Kalinousky· 1 shared A. Szeglowski· 1 shared C. Gaughan· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBioengineering

A. Chiang

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2 papers

Recent·Most cited

Linking collective migration/growth to differentiation boosts global shaping of the transcriptome and exhibits a grasshopper effect for driving maturation

O. Ogoke, D. Guiggey, A. Chiang, S. Thompson, T. H. A. Nguyen, D. Berke, C. Ott, A. Kalinousky, C. Shamul, P. Chen, S. Ross, Z. Chen, P. Srivastava, C. Gaughan, S. D. Mahajan, , N. Parashurama

The paper links collective migration to differentiation in hPSC-derived hepatocytes, showing a significant increase in maturation through a deep-learning gene circuit.

bioRxiv · Jul 24, 2022 · PreprintBioengineering

FOXA1/2 depletion drives global reprogramming of differentiation state and metabolism in a human liver cell line and inhibits differentiation of human stem cell-derived hepatic progenitor cells

I. T. Warren, D. Guiggey, A. Chiang, M. H. Maloy, O. Ogoke, T. S. Groth, T. Mon, S. Meamardoost, X. Liu, S. Thompson, A. Szeglowski, R. Thompson, P. Chen, R. Paulmurugan, M. L. Yarmush, , N. Parashurama

This study shows that depletion of FOXA1/2 in human liver cells reprograms differentiation state and metabolism, promoting de-differentiation and pluripotency.

bioRxiv · Jun 1, 2020Bioengineering