GABA(A) receptor activation drives GABARAP-Nix mediated autophagy to radiation-sensitize primary and brain-metastatic lung adenocarcinoma tumors
D. Bhatacharya, R. Barille, D. K. Toukam, V. S. Gawali, L. Kallay, T. Ahmed, H. Brown, S. Rezvanian, A. Karve, P. B. Desai, M. Medvedovic, K. Wang, D. Ionascu, N. Harun, C. Wang, , S. Sengupta
This paper shows that activating GABA(A) receptors in lung cancer cells triggers autophagy via GABARAP-Nix interaction, enhancing radiation sensitivity and reducing toxicity in preclinical models.
bioRxiv · Nov 29, 2023Cancer Biology