A. Kaznatcheev

Validation of polymorphic Gompertzian model of cancerthrough in vitro and in vivo data

This study validates the polymorphic Gompertzian model using in vitro and in vivo NSCLC data, showing it captures tumor dynamics and relapse trends better than classical models.

The cost of information acquisition by natural selection

This paper challenges Kimura's theory on the cost of information acquisition by natural selection using experimental evolution of E. coli and computational learning theory.

Understanding the Evolutionary Games in NSCLC Microenvironment

The paper uses evolutionary game theory to study non-cell autonomous resistance mechanisms in NSCLC, showing HGF-producing cells outcompete others and support therapy-naive cells.

Measuring competitive exclusion in non-small cell lung cancer

This study measures frequency-dependent interactions between gefitinib-resistant and sensitive NSCLC populations to show that competitive exclusion depends on growth rate data, not just cost of resistance.

IsoMaTrix: a framework to visualize the isoclines of matrix games and quantify uncertainty in structured populations

IsoMaTrix visualizes isoclines of matrix games and quantifies uncertainty in structured populations, showing spatial configuration impacts cancer model dynamics under treatment.

Evolution is exponentially more powerful with frequency-dependent selection

This paper extends algorithmic Darwinism to include frequency-dependent selection, showing it can exponentially speed up adaptation to certain environments.

Computational complexity as an ultimate constraint on evolution

The paper shows that computational complexity can prevent evolution from finding local fitness optima, even in landscapes without reciprocal sign epistasis, and introduces the concept of hard landscapes.

Fibroblasts and Alectinib switch the evolutionary games played by non-small cell lung cancer

The paper develops a game assay to measure evolutionary games in cancer cell co-cultures, showing that fibroblasts and Alectinib shift the game type from Leader to Deadlock.

Fractionated follow-up chemotherapy delays the onset of resistance in bone metastatic prostate cancer

This paper introduces a model showing that fractionated follow-up chemotherapy delays resistance onset in bone metastatic prostate cancer compared to continuous or periodic schedules.