A. Khosla

The transcription factor ATML1 maintains giant cell identity by inducing synthesis of its own (very) long-chain fatty acid-containing ligands

The paper shows that high ATML1 concentrations induce VLCFA synthesis, which maintains giant cell identity by promoting auto-activation through lipid ligand binding.

Cell-type-specific nuclear morphology predicts genomic instability and prognosis in multiple cancer types

The paper develops a deep learning pipeline for nucleus segmentation and featurization in cancer histology, linking nuclear morphology to genomic instability and prognosis across multiple cancer types.

START domain mediates Arabidopsis GLABRA2 transcription factor dimerization and turnover independently of homeodomain DNA binding

This study investigates the role of the START domain in GLABRA2 dimerization and protein turnover, showing it is independent of DNA binding and essential for stability.

Arabidopsis PROTODERMAL FACTOR2 binds lysophosphatidylcholines and transcriptionally regulates phospholipid metabolism

This study shows that PDF2, an HD-Zip IV TF, binds lysophosphatidylcholines via its START domain and regulates phospholipid metabolism in response to phosphate availability.

Rapid analysis of strigolactone receptor activity in a Nicotiana benthamiana dwarf14 mutant

The paper evaluates AtD14 mutants' ability to degrade AtSMXL7 in N. benthamiana D14 mutants, showing that catalytic activity is required for this function.

A series of dual-reporter vectors for ratiometric analysis of protein abundance in plants

The paper introduces a set of dual-reporter vectors for ratiometric analysis of protein abundance in plants, showing that mScarlet-I and luciferases provide high signal-to-noise ratios for transient expression studies.