X. Hu

SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1

This study identifies GLUT1 as a target of SSRIs, showing citalopram inhibits HCC by reversing the Warburg effect through GLUT1 antagonism.

Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells

This study investigates how lactate dehydrogenase (LDH) regulates glycolysis, TCA cycle, and oxidative phosphorylation in cancer cells through kinetic and thermodynamic mechanisms, showing that LDH inhibition disrupts metabolic pathways and induces cell death under hypoxia.

Signal transduction pathways controlling Ins2 gene activity and β cell state transitions

The paper identifies Ins2 gene activity states in beta cells and shows that cAMP activators drive transitions between these states.

Defining cellular determinants of resistance to PD-1 pathway blockade in non-small-cell lung cancer

This study identifies MMP1+ fibroblasts as a cellular determinant of resistance to PD-1 pathway blockade in NSCLC by analyzing single-cell RNA sequencing data and spatial architecture.

Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

This study identifies PRMT inhibitors as effective combinational therapies with PARP inhibitors to sensitize HR-proficient ovarian and breast cancer cells to treatment.

Artesunate, EDTA and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella

This study shows that artesunate, EDTA, and colistin work together to fight Salmonella strains resistant to colistin, by damaging cell membranes and inhibiting MCR-1.

A single cell framework identifies functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis

This study identifies new functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis using multiomic single cell analyses and functional assays.

VGLL2 and TEAD1 fusion proteins drive YAP/TAZ-independent tumorigenesis by engaging p300

This study identifies VGLL2 and TEAD1 fusion proteins as YAP/TAZ-independent drivers of tumorigenesis by recruiting p300 for epigenetic regulation.

PSMA-Guided PROTAC Degraders for Tumor-Specific Protein Degradation in Prostate Cancer

This study develops PSMA-guided PROTACs for prostate cancer, showing they selectively degrade target proteins in PSMA-overexpressing cells and improve therapeutic effects in vivo.

Circular DNA vcDNA-S7 derived from segmented-dsRNA virus BmCPV attenuated viral infection through RNase H1

The paper identifies a novel antiviral mechanism where vcDNA-S7, derived from BmCPV, recruits RNase H1 to degrade viral RNA through heteroduplex formation, thereby suppressing viral replication.

Highly Pathogenic Avian Influenza A (H5N1) clade 2.3.4.4b Virus detected in dairy cattle

The paper identifies a new genotype of HPAI H5N1 virus in dairy cattle, showing genetic changes but lacking key mutations for mammalian adaptation.

Unlocking TAS2R14 activation through intricate multi-ligand binding networks

The paper presents cryo-EM structures of TAS2R14 with ligands and G proteins, revealing multi-ligand binding sites and activation mechanisms.

Interplay of IGF1R and estrogen signaling regulates hematopoietic stem and progenitor cells

This study shows that IGF1R and estrogen signaling interact to regulate HSPC proliferation, with sex-specific effects observed in adult and fetal hematopoiesis.

N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine

This study shows that N-acetylation of α-synuclein enhances its ability to cluster synaptic vesicles via increased interaction with lysophosphatidylcholine.

Schlafen-11 and -9 are innate immune sensors for intracellular single-stranded DNA

The paper identifies Schlafen-11 and -9 as innate immune sensors that recognize intracellular single-stranded DNA containing CGT motifs, leading to cytokine expression and cell death.

Mechanical confinement induces ferroptosis through mitochondrial dysfunction

This study shows that mechanical confinement triggers ferroptosis via mitochondrial dysfunction by inducing Drp1-dependent fragmentation and cPLA2 translocation.

SlWRKY80 recruits SlHDA1 to regulates the tomato fruit ripening and color transformation

This study identifies SlWRKY80's role in tomato fruit ripening and color change by regulating SlSGR1 and SlPSY1 through recruitment of SlHDA1.

Diverse competitor B cell responses to a germline-targeting priming immunogen in human Ig loci transgenic mice

The paper analyzes B cell responses to a germline-targeting immunogen in human Ig loci transgenic mice, finding diverse non-VRC01-class B cells and competitor B cells recognizing epitopes near the VRC01 epitope.

Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants

This paper evaluates RQ3013, an mRNA vaccine against SARS-CoV-2 variants, showing robust immune responses and protection in animal models.

Exclusion of PD-1 from the immune synapse: a novel strategy to modulate T cell function

This paper shows that anti-PD-1 antibodies enhance T cell activation by removing PD-1 from the immune synapse, suggesting a new strategy for cancer immunotherapy.

Macrophage Depletion Protects Against Cisplatin-Induced Ototoxicity and Nephrotoxicity

This study shows that eliminating macrophages with PLX3397 reduces cisplatin-induced hearing and kidney damage by limiting platinum accumulation.

Reprogramming of 3D chromatin domains by antagonizing the β-catenin/CBP interaction attenuates insulin signaling in pancreatic cancer

This study shows that inhibiting β-catenin/CBP interaction with ICG-001 alters 3D chromatin structure in pancreatic cancer, affecting insulin signaling and promoting tumor growth.

cSTAR analysis identifies endothelial cell cycle as a key regulator of flow-dependent artery remodeling

The paper uses cSTAR to analyze endothelial cell transcriptomic states under different flow conditions, identifies CDK2 as a key regulator of artery remodeling.

Non-cell autonomous cardiomyocyte regulation complicates gene supplementation therapy for LMNA cardiomyopathy

This study shows that gene supplementation for LMNA cardiomyopathy is ineffective when targeting cardiomyocytes alone, as non-cell autonomous effects dominate, suggesting alternative therapeutic targets.

MicroRNA-122-mediated liver detargeting enhances the tissue specificity of cardiac genome editing

This study shows that AAV-Tnnt2 vectors leak into the liver, reducing cardiac specificity, and demonstrates that adding miR122 target sequences reduces this leakiness.

Unraveling the dynamic transcriptomic changes during the dimorphic transition of Talaromyces marneffei through time-course analysis

This study identifies dynamic transcriptional changes during the dimorphic transition of Talaromyces marneffei using a novel model, DyGAM-NS, and reveals asymmetrical gene expression patterns and regulatory networks.

Sustained store-operated calcium entry utilizing activated chromatin state leads to instability in iTregs

This study shows that sustained store-operated calcium entry (SOCE) and chromatin accessibility in iTregs lead to phenotypical instability, unlike tTregs.

Morphomechanic tuning of ERK by actin-TFII-IΔ regulates cell identity

The paper shows that actin-TFII-IΔ modulates ERK activity through cell height to direct cell fate during reprogramming.

Spatial redundancy transformer for self-supervised fluorescence image denoising

This paper introduces SRDTrans, a self-supervised denoising transformer for fluorescence images, achieving state-of-the-art performance in single-molecule and two-photon imaging.

A novel bacterial signal transduction system specifically senses and responds to peptidoglycan damage

This study identifies a bacterial two-component system that detects and responds to peptidoglycan damage, revealing its role in antibiotic resistance and tolerance.