A. Prakash

IMD-mediated innate immune priming increases Drosophila survival and reduces pathogen transmission

This study shows that immune priming in Drosophila enhances survival and reduces pathogen transmission by requiring the IMD pathway and Diptericin-B.

Mitochondrial genome variation affects humoral and cell-mediated innate immune responses and infection outcomes

This study shows that mitochondrial DNA variation influences innate immune responses and infection outcomes in Drosophila by affecting gene expression and immune cell function.

Rho and a riboswitch regulate mntP expression evading manganese stress and membrane toxicity

The paper shows Rho terminates transcription at the mntP riboswitch, and manganese activates the riboswitch to restore transcription-translation coupling, preventing membrane toxicity from overexpressed MntP.

Bicyclomycin generates ROS and blocks cell division in Escherichia coli

This study shows that bicyclomycin generates reactive oxygen species (ROS) and causes cell filamentation in E. coli by disrupting DNA partitioning and septum formation.

Regulation of Lung Immune Tone by the Gut-Lung Axis via Dietary Fiber, Gut Microbiota, and Short-Chain Fatty Acids

This study shows that dietary fiber and gut microbiota influence lung immune tone via short-chain fatty acids, reducing inflammation and lung injury in mice.

Mapping the functional form of the trade-off between infection resistance and reproductive fitness under dysregulated immune signaling

This study quantifies the trade-off between immune investment and host fitness by manipulating cactus knock-down in flour beetles, revealing dose-dependent benefits and costs to infection resistance and other fitness traits.

Deciphering the orthorhombic crystal structure of a novel NEIL1 nanobody with pseudo-merohedral twinning

The paper determines the orthorhombic crystal structure of a NEIL1-specific nanobody at 2.1 Å resolution, revealing pseudo-merohedral twinning and resolving over 96% of residues.

Novel genomic offset metrics account for local adaptation in climate suitability forecasts and inform assisted migration

This study develops genomic offset metrics to account for local adaptation in climate suitability forecasts and improves assisted migration strategies for red spruce.

Cell-type-specific nuclear morphology predicts genomic instability and prognosis in multiple cancer types

The paper develops a deep learning pipeline for nucleus segmentation and featurization in cancer histology, linking nuclear morphology to genomic instability and prognosis across multiple cancer types.

Class switching is differentially regulated in RBC alloimmunization and vaccination

This study compares IgG subclass responses to RBC transfusion and alum vaccination, showing differential regulation by STAT6.

Disruption of flour beetle microbiota limits experimentally evolved immune priming response, but not pathogen resistance

This study shows that disrupting the microbiota of flour beetles eliminates immune priming but not pathogen resistance, indicating divergent microbiome reliance in evolved immune strategies.

Lepidopteran prolegs are novel traits, not leg homologs

The paper investigates whether lepidopteran prolegs are serial homologs of thoracic legs, finding they are novel traits with distinct gene regulatory networks.

Ageing leads to nonspecific antimicrobial peptide responses in Drosophila melanogaster

This study shows that ageing in Drosophila melanogaster reduces the specificity of antimicrobial peptide (AMP) responses, requiring multiple AMPs for survival, while young flies can resist infections with single AMPs.

Adverse PFAS effects on mouse oocyte in vitro maturation are associated with carbon-chain length and inclusion of a sulfonate group

This study shows that PFAS toxicity on mouse oocyte in vitro maturation depends on carbon-chain length and presence of sulfonate groups, with longer chains and sulfonates causing more severe reproductive toxicity.

Centrosome Amplification promotes cell invasion via cell-cell contact disruption and Rap-1 activation

This study shows centrosome amplification induces tumourigenic changes in normal breast cells via Rap-1 activation and cell-cell contact disruption.

Genome-wide analysis of PTR/POT transporters in Candida species and their functional characterization in the newly emerged pathogen Candida auris

The paper identifies and characterizes PTR transporters in five Candida species, finding two distinct classes and showing their role in di-/tripeptide uptake and drug resistance in C. auris.

Genomic landscape of the DHA1 family in the newly emerged pathogen Candida auris and mapping substrate repertoire of the prominent member CauMdr1

This study maps the DHA1 family in Candida auris and identifies substrates of CauMdr1, showing overexpression increases antifungal resistance.

Mechanisms of damage prevention, signalling, and repair impact disease tolerance

This study investigates how damage prevention, signaling, and repair mechanisms influence disease tolerance in Drosophila melanogaster, revealing sex-specific differences in tolerance to bacterial infection.

Negative immune regulation contributes to disease tolerance in Drosophila

This study shows that negative immune regulation in Drosophila contributes to disease tolerance by increasing mortality despite reduced bacterial loads.

Duox and Jak/Stat signalling influence disease tolerance in Drosophila during Pseudomonas entomophila infection

This study shows that Duox and Jak/Stat signaling affect disease tolerance in Drosophila during Pseudomonas entomophila infection, with sex-specific effects.

Free spermidine evokes superoxide radicals that manifest toxicity

The paper shows that excess free spermidine generates superoxide radicals, causing toxicity in bacteria lacking the SpeG enzyme, while SpeG enables tolerance by neutralizing spermidine.

Distal-less and spalt are distal organisers of pierid wing patterns

This study investigates the roles of Dll and sal in wing pattern development in Pieris canidia, finding they are required for melanic pattern elements and repress pteridine granule formation.

Captivity-induced behaviour and spatial learning abilities in an enigmatic, aquifer-dwelling blind eel, Rakthamichthys digressus

This study examines how captivity affects behavior and spatial learning in the blind eel Rakthamichthys digressus, finding altered behaviors but no change in behavioral syndromes or spatial learning ability.

THE COSTS AND BENEFITS OF BASAL INFECTION RESISTANCE VS DIVERSE IMMUNE PRIMING RESPONSES IN AN INSECT

This study compares the fitness costs and benefits of immune priming versus basal resistance in Tribolium beetles, finding resistance provides greater reproductive and survival advantages with no hidden costs.

Berberine as siderophore from Talaromyces trachyspermus: augmentation and characterization".

The paper optimizes and characterizes berberine production by Talaromyces trachyspermus, identifying it as a catecholate siderophore with clinical relevance.

Lung Immune Tone Regulation by the Gut-Lung Immune Axis: Short-chain Fatty Acid Receptors FFAR2 and FFAR3, and IL-1β Expression Profiling in Mouse and Human Lung

This study investigates how gut microbiome-derived short-chain fatty acids (SCFAs) and their receptors FFAR2/FFAR3 regulate lung immune tone through IL-1β expression in mouse and human lung tissues.

Modulation of macrophage defense responses by Mycobacterial persistence protein MprA (Rv0981) in human THP-1 cells: effect of single amino acid variation on host-pathogen interactions

This study shows that the MprA variant G70S in M. tuberculosis reduces phago-lysosome fusion and increases immune suppressive cytokines in THP-1 macrophages, supporting pathogen persistence.

Long-term metabolic consequences of acute dioxin exposure differ between male and female mice

This study examines the long-term metabolic effects of acute dioxin exposure in male and female mice, revealing sex-dependent differences in insulin levels and beta cell function.

Doublesex mediates the development of sex-specific pheromone organs in Bicyclus butterflies via multiple mechanisms

This study investigates the evolution and molecular basis of sex-specific pheromone organs in Bicyclus butterflies, showing that the gene doublesex (dsx) regulates their development through spatial and isoform-specific mechanisms.

Development and Application of a High-Content Virion Display Human GPCR Array

The paper develops a high-content Virion Display (VirD) array of human GPCRs to profile their biochemical activities and identifies potential drug targets.