Resident memory T cell development is associated with AP-1 transcription factor upregulation across anatomical niches.
N. P. Smith, Y. Yan, Y. Pan, J. B. Williams, K. Manakongtreecheep, S. Pant, J. Zhao, T. Tian, T. Pan, C. Stingley, K. Wu, J. Zhang, A. L. Kley, P. K. Sorger, A.-C. Villani, T. S. Kupper
This study identifies AP-1 transcription factors as key regulators of TRM development across tissues using scRNA-seq and ATAC-seq, revealing a novel mechanism for TRM reactivation.
bioRxiv · Sep 29, 2023 · PreprintImmunology