Author

A. L. Rothman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Research Focus:variant calling· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Srikiatkhachorn· 3 shared H. Friberg· 3 shared J. R. Currier· 3 shared S. Fernandez· 3 shared T. Li· 3 shared A. Waickman· 2 shared C. Fung· 2 shared D. Ellison· 2 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersEvolutionary Biology

A. Srikiatkhachorn

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Monomeric IgA antagonizes IgG-mediated enhancement of DENV infection

A. Wegman, H. Fang, A. L. Rothman, S. J. Thomas, T. P. Endy, M. K. McCracken, J. R. Currier, H. Friberg, G. D. Gromowski, A. T. Waickman

This study shows that monomeric IgA can neutralize DENV and block IgG-mediated antibody-dependent enhancement (ADE) in vitro.

bioRxiv · Sep 14, 2021Immunology

Vector and cell-culture passaging of dengue clinical samples for virus isolation and amplification does not significantly change genome consensus or frequencies of intra-host viral variants

C. Fung, T. Li, S. Pollett, M. T. Alera, I.-K. Yoon, J. Hang, L. Macareo, A. Srikiatkhachorn, D. Ellison, A. L. Rothman, S. Fernandez, R. G. Jarman, I. Maljkovic Berry

This study shows that low-passage dengue virus isolates preserve the consensus sequence and intra-host variant frequencies of their clinical samples, making them suitable for genomic epidemiology.

bioRxiv · Aug 17, 2020 · PreprintEvolutionary Biology

Temporally integrated single cell RNA sequencing analysis of controlled and natural primary human DENV-1 infections

A. Waickman, H. Friberg, G. Gromowski, W. Rutvisuttinunt, T. Li, H. Siegfried, K. Victor, M. McCracken, S. Fernandez, A. Srikiatkhachorn, D. Ellison, R. G. Jarman, S. Thomas, A. L. Rothman, T. Endy, J. R. Currier

The paper compares the transcriptional responses of controlled and natural primary DENV-1 infections using scRNA-seq, finding similar inflammatory responses but more pronounced suppression of translation and mitochondrial function in natural infections.

bioRxiv · Jul 16, 2020Immunology

Analysis of cell-associated DENV RNA by oligo(dT) primed 5' capture scRNAseq

M. A. Sanborn, T. Li, K. Victor, H. Siegfried, C. Fung, A. L. Rothman, A. Srikiatkhachorn, S. Fernandez, D. W. Ellison, R. Jarman, H. Friberg, I. Maljkovic Berry, J. R. Currier, A. Waickman

This study uses 5' capture scRNAseq to detect and quantify DENV RNA in infected cells, revealing viral sequence variability and identifying infected cell types.

Scientific Reports · Jun 3, 2020Peer-reviewedMicrobiology