C. Fung

Tuft cell-derived acetylcholine regulates epithelial fluid secretion

This study shows that tuft cell-derived acetylcholine in the intestine triggers immediate fluid secretion, distinct from its role in immune responses, and is involved in Type 2 inflammation and helminth clearance.

Tuft cells mediate commensal remodeling of the small intestinal antimicrobial landscape

This study shows that succinate from commensal protists activates tuft cells, leading to changes in antimicrobial peptides and microbiota composition in the small intestine.

An infection-activated redox switch promotes tumor growth

The paper shows that oxidation of legumain at Cys219 by H. pylori infection promotes tumor growth and mortality in a xenograft model.

Spatiotemporal heterogeneity of glioblastoma is dictated by microenvironmental interference

This study identifies microenvironmental factors driving transcriptional heterogeneity in glioblastomas through spatial transcriptomics, metabolomics, and proteomics.

Vector and cell-culture passaging of dengue clinical samples for virus isolation and amplification does not significantly change genome consensus or frequencies of intra-host viral variants

This study shows that low-passage dengue virus isolates preserve the consensus sequence and intra-host variant frequencies of their clinical samples, making them suitable for genomic epidemiology.

Analysis of cell-associated DENV RNA by oligo(dT) primed 5' capture scRNAseq

This study uses 5' capture scRNAseq to detect and quantify DENV RNA in infected cells, revealing viral sequence variability and identifying infected cell types.

Lineage and Spatial Mapping of Glioblastoma-associated Immunity

This study maps immune cell states and interactions in glioblastoma, identifying IL-10-driven T cell exhaustion and myeloid-lymphoid interactions contributing to immunosuppression.