ImmunologybioRxiv
Clonal replacement of tumor-specific T cells following PD-1 blockade
K. E. Yost, A. T. Satpathy, D. K. Wells…·H. Y. Chang
This study tracks T cell clonal dynamics before and after PD-1 blockade in cancer patients, finding that new T cell clones, not pre-existing ones, expand in response to treatment.