C. Curtis

Rampant transcription replication conflict creates therapeutic vulnerability in extrachromosomal DNA containing cancers

This paper identifies transcription-replication conflict as a vulnerability in ecDNA-containing cancers and demonstrates that CHK1 inhibition selectively kills these tumors.

The G1/S transition is promoted by Rb degradation via the E3 ligase UBR5

The paper identifies UBR5-mediated Rb degradation as a mechanism promoting G1/S transition by reducing Rb levels in early G1.

Analysis of ductal carcinoma in situ by self-reported race reveals molecular differences related to outcome.

The paper analyzes molecular differences in ductal carcinoma in situ (DCIS) by self-reported race and outcome groups, identifying variations in gene expression, tumor microenvironment, and copy number variations between Black and White women.

Germline-mediated immunoediting sculpts breast cancer subtypes and metastatic proclivity

This study shows germline variants influence somatic evolution in breast cancer by modulating immunoediting, affecting tumor subtype and metastatic potential.

Development and characterization of new patient-derived xenograft (PDX) models of osteosarcoma with distinct metastatic capacities

The paper develops and characterizes new osteosarcoma PDX models with varying metastatic capacities to study disease biology and test therapeutic interventions.

A microwell platform for high-throughput longitudinal phenotyping and selective retrieval of organoids

This paper introduces a microwell platform for high-throughput longitudinal phenotyping of organoids and their selective retrieval for molecular profiling, identifying genomic and expression changes linked to growth and polarity.

Cancers adapt to their mutational load by buffering protein misfolding stress

The paper shows high mutational load tumors upregulate proteostasis machinery to buffer protein misfolding stress, revealing therapeutic vulnerabilities.

Engineered extracellular matrices reveal stiffness-mediated chemoresistance in patient-derived pancreatic cancer organoids

This study shows that high stiffness engineered matrices induce chemoresistance in pancreatic cancer organoids through hyaluronan mechanosignaling and a plastic cancer stem cell phenotype.

Deterministic evolution and stringent selection during pre-neoplasia

This study models pre-neoplasia in human gastric organoids by inactivating TP53, revealing progression to malignant transcriptional programs and clonal dynamics through experimental evolution.

The Mettl3 epitranscriptomic writer amplifies p53 stress responses

This paper identifies Mettl3 as a p53-interacting protein that stabilizes p53 and enhances its tumor suppressive functions through both protein stabilization and m6A modification of p53 pathway transcripts.

Pan-cancer organoid validation of tumor outlier chromosomal amplification events

The paper validates oncogenic chromosomal amplification events across multiple cancers using organoid models and functional assays.

DCIS genomic signatures define biology and clinical outcome: Human Tumor Atlas Network (HTAN) analysis of TBCRC 038 and RAHBT cohorts

The paper develops a classifier for DCIS recurrence using genomic data from two cohorts and identifies pathways and stroma-specific signatures associated with progression to invasive cancer.

Most cancers carry a substantial deleterious load due to Hill-Robertson interference

This study shows that most cancers do not remove deleterious mutations due to Hill-Robertson interference, leading to a 40% average fitness cost per cell.

Convergent mutations in tissue-specific regulatory regions reveal novel cancer drivers

This study identifies non-coding cancer drivers by analyzing convergent mutations in tissue-specific regulatory regions across multiple cancer types, finding several genes associated with survival.

Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases

This study analyzes exome sequencing data from paired primary tumors and metastases to investigate clonality and timing of metastatic spread across cancers.

Clonal replacement of tumor-specific T cells following PD-1 blockade

This study tracks T cell clonal dynamics before and after PD-1 blockade in cancer patients, finding that new T cell clones, not pre-existing ones, expand in response to treatment.

Mitogenomic Diversity in Sacred Ibis Mummies sheds light on early Egyptian practices

The paper analyzes mitochondrial genomes of Sacred Ibis mummies to determine how ancient Egyptians obtained birds for mummification, finding high genetic diversity suggesting wild taming rather than centralized farming.

Quantification of subclonal selection in cancer from bulk sequencing data

This study quantifies subclonal selection in cancer using bulk sequencing data to determine mutation rates, selective advantages, and subclone emergence times in gastric and lung cancers.