Author

A. Lindqvist

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Approach:biophysical modeling· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. W. Middleton· 2 shared K. Akopyan· 2 shared A. B. Munoz-Manchado· 1 shared A. Lopez-Pascual· 1 shared C. Louvet· 1 shared E. Mullers· 1 shared H. Silva Cascales· 1 shared H. Stoy· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

A. W. Middleton

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Author profile →

4 papers

Recent·Most cited

Wee1 inhibition decouples Cdk1 and Plk1 activities: a role for gradual Cdk1 activation throughout G2 phase.

K. Akopyan, A. Lindqvist

This study shows that gradual Cdk1 activation during G2 phase coordinates mitotic factor production and CDK1/PLK1 activation, and that WEE1 inhibition disrupts this coordination.

bioRxiv · Mar 15, 2024 · PreprintCell Biology

Single-cell mRNA-regulation analysis reveals cell type-specific mechanisms of type 2 diabetes

J. Martinez-Lopez, A. Lindqvist, A. Lopez-Pascual, P. Chen, L. Shcherbina, S. Chriett, N. G. Skene, R. B. Prasad, M. Lancien, P. F. Johnson, P. Eliasson, C. Louvet, A. B. Munoz-Manchado, R. Sandberg, J. Hjerling-Leffler, N. Wierup

This study uses single-cell RNA sequencing and network analysis to identify cell type-specific gene dysregulation mechanisms in type 2 diabetes.

bioRxiv · Mar 23, 2023 · PreprintCell Biology

Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate Plk1

H. Silva Cascales, K. Burdova, A. W. Middleton, V. Kuzin, E. Mullers, H. Stoy, L. Baranello, L. Macurek, A. Lindqvist

This study shows Cyclin A2 localizes to the cytoplasm at the S/G2 transition to activate PLK1 by interacting with Bora, and this cytoplasmic presence is restricted by p21.

bioRxiv · Jul 29, 2020Cell Biology

p53-dependent polyploidisation after DNA damage in G2 phase

A. W. Middleton, R. Suman, P. O'Toole, K. Akopyan, A. Lindqvist

This study shows that G2 phase cell cycle exit in p53-positive cells can lead to polyploidisation through repeated DNA re-replication rather than senescence.

bioRxiv · Jun 9, 2020 · PreprintCell Biology