Author

L. Baranello

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:proteomics· 2

Frequent Co-Authors

D. P. Cameron· 3 shared J. Grosser· 2 shared V. Kuzin· 2 shared A. Lindqvist· 1 shared A. Mizi· 1 shared A. Papantonis· 1 shared A. Tannapfel· 1 shared A. W. Middleton· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCancer Biology

D. P. Cameron

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Co-inhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcription

D. P. Cameron, J. Grosser, S. Ladigan, V. Kuzin, E. Iliopoulou, A. Wiegard, H. Benredjem, S. T. Liffers, S. Lueong, P. F. Cheung, D. Vangala, M. Pohl, R. Viebahn, C. Teschendorf, H. Wolters, , L. Baranello

The paper shows that combining TOP1 and BRD4 inhibitors selectively kills pancreatic cancer cells by inducing readthrough transcription, without harming normal cells.

bioRxiv · Feb 10, 2023Cancer Biology

The Epstein-Barr virus ubiquitin deconjugase BPLF1 regulates the activity of Topoisomerase II during virus replication

J. Li, N. Nagy, J. Liu, S. Gupta, T. Frisan, T. Hennig, D. P. Cameron, L. Baranello, M. G. Masucci

This study identifies BPLF1 as a regulator of TOP2 activity during EBV replication by modulating ubiquitination, SUMOylation, and DNA-damage response.

bioRxiv · Feb 26, 2021Microbiology

The assisting role of Polη in transcription facilitates formation of damage-induced cohesion

L. Ström, P.-S. Wu, D. P. Cameron, J. Grosser, L. Baranello

This paper shows that Polη assists transcription, which facilitates damage-induced cohesion in yeast.

bioRxiv · Dec 20, 2020 · PreprintCell Biology

Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate Plk1

H. Silva Cascales, K. Burdova, A. W. Middleton, V. Kuzin, E. Mullers, H. Stoy, L. Baranello, L. Macurek, A. Lindqvist

This study shows Cyclin A2 localizes to the cytoplasm at the S/G2 transition to activate PLK1 by interacting with Bora, and this cytoplasmic presence is restricted by p21.

bioRxiv · Jul 29, 2020Cell Biology

Spatial chromosome folding and active transcription drive DNA fragility and formation of oncogenic MLL translocations

H. J. Gothe, B. A. M. Bouwman, E. G. Gusmao, R. Piccinno, S. Sayols, O. Drechsel, G. Petrosino, V. Minneker, N. Josipovic, A. Mizi, C. F. Nielsen, E.-M. Wagner, S. Takeda, H. Sasanuma, D. F. Hudson, , V. Roukos

The paper shows that transcription and spatial chromosome folding increase DNA fragility, leading to oncogenic translocations in leukemia.

bioRxiv · Dec 3, 2018Cell Biology