Loss of endogenous estrogen alters mitochondrial metabolism and muscle clock-related protein Rbm20 in female mdx mice
C. A. Timpani, D. Debrincat, S. Kourakis, R. Boyer, L. E. Formosa, J. R. Steele, H. Zhang, R. B. Schittenhelm, A. P. Russell, E. Rybalka, A. Lindsay
This study shows that estrogen loss in female mdx mice reduces exercise capacity and mitochondrial metabolism, but estrogen replacement therapy can reverse these effects and upregulate Rbm20.
bioRxiv · Feb 8, 2024 · PreprintPathology